Anti-IL-18 (Clone 125-2H) (Human) mAb (Monoclonal Antibody)

IL-18 Monoclonal Antibody.

Specifications:

Description

Monoclonal antibody of 100 μg targeting IL-18 for ELISA, IPP, NT.

Target: IL-18
Product Type: Antibody
Size: 100 μg
Application: ELISA, IP, NT
Research Area / Disease: Immunology
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 125-2H
Concentration: 1 mg/mL
Formulation: 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG1
Immunogen: Recombinant human IL-18
Host Species: Mouse
Species Reactivity: Human
Source: This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18.
Reactivity: This antibody reacts with human IL-18on Western blotting.
Gene ID Human:

10068

Gene ID Mouse:

16173

Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Nussbaumer O et al. DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes. Blood. 118, 2743-51 (2011),
  2. Okano M et al. Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis. Int Arch Allergy Immunol. 160, 275-86 (2013),
  3. Shida K et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 166, 6671-9 (2001),
  4. Skurk T et al. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol. 152, 863-8 (2005),
  5. Sugawara S et al. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol. 167, 6568-75 (2001),
  6. Tu Z et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J Exp Med. 205, 233-44 (2008)
  7. Nussbaumer, O., et al., Blood 118, 2743-2751 (2011)
  8. Tu, A., et al., J. Exp. Med. 205, 233-244 (2008)
  9. Wu, C., J. Immunol. 170, 5571-5577 (2003)
  10. Sugawara, S., J. Immunol. 167, 6568-6575 (2001)
  11. Skurk T, Kolb H, Müller-scholze S, Röhrig K, Hauner H, Herder C. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol. 2005;152(6):863-8.
  12. Nagai T, Devergne O, Mueller TF, Perkins DL, Van seventer JM, Van seventer GA. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol. 2003;171(10):5233-43.
  13. Shida K, Shiratori I, Matsumoto M, et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 2001;166(11):6671-9.
  14. Vankayalapati R, Wizel B, Weis SE, Samten B, Girard WM, Barnes PF. Production of interleukin-18 in human tuberculosis. J Infect Dis. 2000;182(1):234-9.
  15. Bossù P et al. Anti-inflammatory Effects of Homotaurine in Patients With Amnestic Mild Cognitive Impairment. Front Aging Neurosci. 10, 85 (2018)
  16. Pal A et al. Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides. Sci Rep. 9, 4913 (2019)

References

  1. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
  2. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
  3. Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
  4. Okamura, H., et al., Nature 378, 88-91 (1995)
Code D044-3
Product Type Antibody
Size 100 μg
Application ELISA, IP, NT
Price
$328.61
Qty: