Anti-IL-18 (Clone 125-2H) (Human) mAb (Monoclonal Antibody)
IL-18 Monoclonal Antibody.
Specifications:
Description
Monoclonal antibody for targeting IL-18 for ELISA, IC, IPP, NT.
| Target: | IL-18 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | ELISA, IP, NT |
| Research Area / Disease: | Immunology |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 125-2H |
| Concentration: | 1 mg/mL |
| Formulation: | 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human IL-18 |
| Host Species: | Mouse |
| Species Reactivity: | Human |
| Source: | This antibody was purified from hybridoma (clone 125-2H) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Balb/c mouse splenocyte immunized with recombinant human IL-18. |
| Reactivity: | This antibody reacts with human IL-18 on Immunoprecipitation. |
| Gene ID Human: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Nussbaumer O et al. DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes. Blood. 118, 2743-51 (2011),
- Okano M et al. Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis. Int Arch Allergy Immunol. 160, 275-86 (2013),
- Shida K et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 166, 6671-9 (2001),
- Skurk T et al. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol. 152, 863-8 (2005),
- Sugawara S et al. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol. 167, 6568-75 (2001),
- Tu Z et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J Exp Med. 205, 233-44 (2008)
- Nussbaumer, O., et al., Blood 118, 2743-2751 (2011)
- Tu, A., et al., J. Exp. Med. 205, 233-244 (2008)
- Wu, C., J. Immunol. 170, 5571-5577 (2003)
- Sugawara, S., J. Immunol. 167, 6568-6575 (2001)
- Skurk T, Kolb H, Müller-scholze S, Röhrig K, Hauner H, Herder C. The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol. 2005;152(6):863-8.
- Nagai T, Devergne O, Mueller TF, Perkins DL, Van seventer JM, Van seventer GA. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol. 2003;171(10):5233-43.
- Shida K, Shiratori I, Matsumoto M, et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 2001;166(11):6671-9.
- Vankayalapati R, Wizel B, Weis SE, Samten B, Girard WM, Barnes PF. Production of interleukin-18 in human tuberculosis. J Infect Dis. 2000;182(1):234-9.
- Bossù P et al. Anti-inflammatory Effects of Homotaurine in Patients With Amnestic Mild Cognitive Impairment. Front Aging Neurosci. 10, 85 (2018)
- Pal A et al. Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides. Sci Rep. 9, 4913 (2019)
- Chirita, D., Bronnec, P., Magnotti, F. et al. Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation. Cell Death Dis 14, 213 (2023). https://doi.org/10.1038/s41419-023-05745-9
References
- Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
- Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
- Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
- Okamura, H., et al., Nature 378, 88-91 (1995)
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