Anti-IL-18 (Clone 25-2G) (Human) mAb (Monoclonal Antibody)
IL-18 Monoclonal Antibody.
Specifications:
Description
Monoclonal antibody of 100 µl targeting IL-18 for IHC, WB.
| Target: | IL-18 |
|---|---|
| Product Type: | Antibody |
| Size: | 100 µl |
| Application: | IHC, WB |
| Research Area / Disease: | Immunology |
| Conjugate: | Unlabeled |
| Antibody Type: | Monoclonal |
| Clone Number: | 25-2G |
| Concentration: | 1 mg/mL |
| Formulation: | 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human IL-18 |
| Host Species: | Mouse |
| Species Reactivity: | Human |
| Source: | This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18. |
| Reactivity: | This antibody reacts with human IL-18on Western blotting. |
| Gene ID Human: | |
| Gene ID Mouse: | |
| Storage Temperature: | -20°C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Citations
- Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren’s syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol. 2008;181(4):2898-906.
- Omoto Y, Tokime K, Yamanaka K, et al. Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol. 2006;177(12):8315-9.
- Takiyama Y, Miyokawa N, Tokusashi Y, et al. Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. Thyroid. 2002;12(11):935-43.
- Shida K, Shiratori I, Matsumoto M, et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 2001;166(11):6671-9.
- Guo H et al. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats. Mediators Inflamm. 2018, 7304096 (2018)
References
- Sakai, A., et al., J. Immunol. 181, 2898-2906(2008)
- Takiyama, Y., et al., Thyroid 12, 935-943 (2002)
- Shida, K., et al., J. Immunol. 166, 6671-6679 (2001)
- Akita, K., et al., J. Biol. Chem. 272, 26595-26603 (1997)
- Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
- Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
- Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
- Okamura, H., et al., Nature 378, 88-91 (1995)
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Pathway Posters
Rho Family Pathway
