Anti-IL-18 (Clone 25-2G) (Human) mAb (Monoclonal Antibody)

IL-18 Monoclonal Antibody.

Specifications:

Description

Monoclonal antibody of 100 µl targeting IL-18 for IHC, WB.

Target: IL-18
Product Type: Antibody
Size: 100 µl
Application: IHC, WB
Research Area / Disease: Immunology
Conjugate: Unlabeled
Antibody Type: Monoclonal
Clone Number: 25-2G
Concentration: 1 mg/mL
Formulation: 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Isotype: IgG1
Immunogen: Recombinant human IL-18
Host Species: Mouse
Species Reactivity: Human
Source: This antibody was purified from mouse ascitesfluid using proteinA agarose. This hybridoma wasestablished by fusion of mouse myeloma cell SP2/0 withBalb/c mouse splenocyte immunized with recombinanthuman IL-18.
Reactivity: This antibody reacts with human IL-18on Western blotting.
Gene ID Human:

3606

Gene ID Mouse:

16173

Storage Temperature: -20°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren’s syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol. 2008;181(4):2898-906.
  2. Omoto Y, Tokime K, Yamanaka K, et al. Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol. 2006;177(12):8315-9.
  3. Takiyama Y, Miyokawa N, Tokusashi Y, et al. Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. Thyroid. 2002;12(11):935-43.
  4. Shida K, Shiratori I, Matsumoto M, et al. An alternative form of IL-18 in human blood plasma: complex formation with IgM defined by monoclonal antibodies. J Immunol. 2001;166(11):6671-9.
    1. Guo H et al. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats. Mediators Inflamm. 2018, 7304096 (2018)

    References

    1. Sakai, A., et al., J. Immunol. 181, 2898-2906(2008)
    2. Takiyama, Y., et al., Thyroid 12, 935-943 (2002)
    3. Shida, K., et al., J. Immunol. 166, 6671-6679 (2001)
    4. Akita, K., et al., J. Biol. Chem. 272, 26595-26603 (1997)
    5. Dao, T., et al., Cell Immunol. 173, 230-235 (1996)
    6. Micallef, M., et al., Eur. J. Immunol. 26, 1647-1651 (1996)
    7. Ushio, S., et al., J. Immunol. 156, 4274-4279 (1996)
    8. Okamura, H., et al., Nature 378, 88-91 (1995)
    Code D043-3
    Product Type Antibody
    Size 100 µl
    Application IHC, WB
    Price
    $306.33
    Qty: