Anti-Fas Ligand (CD178) (Human) mAb-PE

  • Applications
    • FCM
    • NT
  • Target Fas
  • Host Species Hamster
  • Species Reactivities Human
  • Code # D041-5
  • Size 50 Tests
  • Price
    $334.18
Specifications

Background

Fas ligand (FasL/CD178/CD95L) is a type II-membrane protein, belonging the tumor necrosis factor (TNF)/nerve growth factor (NGF) family. It is known that engagement of Fas (receptor of FasL) by FasL causes apoptotic cell death. FasL is predominantly expressed in activated T lymphocytes and Natural Killer (NK) cells and expressed in the tissues of the immune-privilege sites such as the testis and eye. On the other hand, Fas is expressed in various tissues with abundant expression in the thymus, liver, heart, and kidney. Furthermore, a vari ety of cancers such as melanomas were found to express FasL in addition to Fas. It is said that, Fas/FasL system is involved in the deletion of dangerous activated or autoreactive T and B cells, and in turn plays a role in human diseases such as fulminant hepatitis, AIDS, cancers and other diseases involving CTL-induced tissue destruction. Furthermore, FasL can be used as an immune-suppressive agent. Rejection of transplants is mediated by activated T cells that may express functional Fas. If a transplanted tissue is engineered to express FasL or is co-transplanted with FasL-expressing cells, the transplant may be tolerated.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM, NT
  • Clone Number:
    4H9
  • Concentration:
    1 mg/mL
  • Conjugate:
    PE
  • Description:
    Monoclonal antibody of 50 tests targeting Fas for FCM, NT.
  • Formulation:
    50 tests in 1mL volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty ofwater when disposing materials containing azide into drain.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Hamster
  • Immunogen:
    Recombinant human Fas ligand
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human Fas Ligand on Flow cytometry.
  • Research Area:
    Apoptosis
  • Short Description:
    Fas Monoclonal Antibody.
  • Size:
    50 Tests
  • Species Reactivity:
    Human
  • Storage Temperature:
    4°C
  • Target:
    Fas
References
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  2. Zanin-Zhorov, A., et al., J. Immunol. 171, 5882-5889 (2003)
  3. Suhara, T., et al., Mol. Cell. Biol. 22, 680-691 (2002)
  4. Chiou, S., et al., J. Immunol. 167, 4098-4103 (2001)
  5. Tateyama, M., et al., Blood 96, 195-202 (2000)
  6. Gastman, B. R., et al., Cancer Res. 59, 5356-5364 (1999)
  7. Sata, M. and Walsh, K., J. Clin. Invest.102, 1682-1689 (1998)
  8. Suda, T., et al., J. Exp. Med.186, 2045-2050 (1997)
  9. Sato, K., et al., Br. J. Haematol. 94, 379-382 (1996)
  10. Tanaka, M., et al., Nature Medicine 2, 317-322(1996)