Anti-Proton Pump (H, K-ATPase α subunit) (Mouse) mAb

  • Applications
    • IHC
  • Target Proton pump
  • Host Species Rat
  • Species Reactivities Bovine, Human, Mouse, Rat
  • Code # D031-3H
  • Size 6 mL
  • Price
    $183.80
Specifications

Background

Hydrogen-potassium adenosine triphosphatase (H + , K + -ATPase) belongs to a family of P-type cation-transporting ATPases that also includes Ca 2+ -ATPase and Na + , K + -ATPase. H + , K + -ATPase is responsible for acid secre tion into the stomach and catalyzes electroneutral excha nge of cytoplasmic hydrogen ions and external potassium ions coupled with ATP hydrolysis. The enzyme is found in gastric parietal cells where it is located in cytoplasmi c vesicles or apical plasma membranes of the secretory canaliculus. H + , K + -ATPase is a heterodimer consisting of a high molecular weight catalytic α subunit and a smaller but heavily glycosylated α subunit. The α subunit of H + , K + -ATPase has 10 transmembrane domains and contains sites for ATP binding and its acylphosphorylation, binding sites of proton pump inhibitors, and sites responsible for ion recognition.
  • Antibody Type:
    Monoclonal
  • Application:
    IHC
  • Clone Number:
    1H9
  • Conjugate:
    Unlabeled
  • Description:
    Monoclonal antibody of 6 ml targeting Proton pump (H,K-ATPase α subunit) for IHC.
  • Formulation:
    Prepared from cµlture supernatant with preservative (0.09% sodium azide)
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Gene ID (Rat):
  • Host Species:
    Rat
  • Immunogen:
    This product is an antibody obtained from a hybridoma by fusing mouse myeloma cells and spleen cells BALB / c nu / + mouse neonatal thymectomy anti-gastric wall cells to produce antibodies.
  • Isotype:
    IgG1
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human,mouse, rat and bovine H+, K+-ATPaseαsubunit.
  • Research Area:
    Apoptosis
  • Short Description:
    Proton pump (H,K-ATPase α subunit) Monoclonal Antibody.
  • Size:
    6 mL
  • Species Reactivity:
    Bovine, Human, Mouse, Rat
  • Storage Temperature:
    4°C
  • Target:
    Proton pump
References
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  3. Murphy, K., et al., Int. Immunol. 15, 269-277 (2003)
  4. Laurie, K. L., et al., J. Immunol. 169, 2361-2367 (2002)
  5. Kimura, T., et al., J. Biochem. 131, 923-932 (2002)
  6. Kimura, T., et al., J. Biol. Chem. 277, 20671-20677 (2002)
  7. Biondo, M., et al., J. Immunol. 166, 2090-2099 (2001)
  8. Alderuccio, F., et al., Int. Immunol. 12, 343-352 (2000)
  9. Jones, C. M., et al., Gastroenterology 101, 287-294 (1991)
  10. Toh, B., et al., PNAS 87, 6418-6422 (1990)
  11. Mori, Y., et al., Gastroenterology 97, 364-375 (1989)