Anti-CD66c (KOR-SA3544) (Human) mAb-PE

  • Applications
    • FCM
    • WB
  • Target KOR-SA3544
  • Host Species Mouse
  • Species Reactivities Human
  • Code # D028-5
  • Size 50 Tests
  • Price
    $306.33
Specifications

Alternative Names

CEACAM6, NCA, CEAL

Background

This monoclonal antibody (clone KOR - SA3544 ) was reactive with a surface antigen expressed on Philadelphia chromosome (Ph 1 ) - positive acute lymphoblastic leukemia (ALL) without exception (26/26 cases). The recognized antigen is a nonspecific cross - reacting antigen (NCA) - 50/90 (CD66c), one of the carcinoe mbryonic antigen (CEA) - related glycoproteins encoded by a member of the CEA gene family. The Philadelphia chromosome (Ph 1 ) has been implicated as the causative factor in greater than 90% of chronic myelogenous leukemia (CML), in 25 – 30% of adult and 2 – 10 % of childhood acute lymphoblastic leukemia (ALL) and in rare cases of acute myelogenous leukemia (AML). The presence of the Ph in leukemic cells of ALL patients usually indicates poor prognosis and high risk. Sequential monitoring of the Ph in ALL correla tes with the activity of malignant clones and predicts impending clinical relapse, and therefore is useful in guiding clinical therapeutic decisions.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM, WB
  • Clone Number:
    KOR-SA3544
  • Conjugate:
    PE
  • Description:
    Monoclonal antibody of 50 tests targeting KOR-SA3544 for FCM, WB.
  • Formulation:
    50 tests in 1mL volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty ofwater when disposing materials containing azide into drain.
  • Gene ID (Human):
  • Host Species:
    Mouse
  • Immunogen:
    KOCL-22 myeloid cell line derived from congenital leukemia
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    The reactivity of this antibody has been reported as follows. Common ALL a 5/38 (13.2%) Early B precursor ALL b 1 c /21 (4.8%) T - ALL 0/19 B - ALL 0/6 B - CLL/HCL 0/3 Multiple myelo ma 0/2 ANLL 16/56 (28.6%) Ph1 - ALL 26/26 d (100%) CML blastic crisi
  • Research Area:
    Cell Biology
  • Short Description:
    KOR-SA3544 Monoclonal Antibody.
  • Size:
    50 Tests
  • Species Reactivity:
    Human
  • Storage Temperature:
    4°C
  • Target:
    KOR-SA3544
References
  1. Sugita, K., et al., Leukemia 13, 779-785 (1999)
  2. Mori, T., et al., Leukemia 9, 1233-1239 (1995)