CircuLex PCSK9 D374Y (His-tagged)

CircuLex PCSK9 D374Y (His-tagged).



CircuLex PCSK9 D374Y (His-tagged) of 10 µg and The PCSK9 D374Y demonstrates 64 kDa (catalytic and C-terminal domain) and 16 kDa (prodomain band) by SDS-PAGE analysis.

Target: PCSK9
Product Type: Recombinant Protein
Size: 10 μg
Research Area / Disease: Metabolism
Concentration: 100 μg/mL
Formulation: The PCSK9 D374Y is supplied frozen in PBS pH 7.2, 10 % glycerol.
Source: Full length human PCSK9 having one mutation D374Y, containing C-terminal His-tag, expressed in HEK 293 cells.
Gene ID Human:


Gene ID Mouse:


Purity: The PCSK9 D374Y is greater than 95% pure as determined by SDS-PAGE analysis.
Storage Temperature: -70°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.


  1. Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M (2003) Proc Natl Acad Sci USA 100:928–933.
  2. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, et al. (2003) Nat Genet 34:154–156.
  3. Leren TP (2004) Clin Genet 65:419–422.
  4. Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP, Fredenrich A, et al. (2005) Hum Mutat 26:497.
  5. Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264–1272.
  6. Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094–1100.
  7. Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100–7105.
  8. Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD (2005) Proc Natl Acad Sci USA 102:5374–5379.
  9. Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995–3005 10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum. Mol. Genet. 15, 1551–1558
  10. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602–18612
  11. Hyock Joo Kwon*, Thomas A. Lagace†, Markey C. McNutt†, Jay D. Horton†‡, and Johann Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820–1825.
Code CY-R2331
Product Type Recombinant Protein
Size 10 μg

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