CircuLex PCSK9 Wild Type

  • Code # CY-R2330
  • Size 50 µg
  • Price
    $551.40
Specifications

Background

PCSK9 binds to the LDL receptor in vitro and in vitro. Human PCSK9 wild type containing a C-terminal His-tag, expressed in HEK 293 cells. Binding capability to EGF-AB domain of LDL receptor was confirmed by using CircuLex PCSK9-LDLR in vitro Binding Assay Kit (CY-8150).
  • Description:

    CircuLex PCSK9 Wild Type of 50 µg and The PCSK9 Wild Type demonstrates 62 kDa (catalytic and C-terminal domain) and 16 kDa (prodomain band) by SDS-PAGE analysis.

  • Formulation:
    The PCSK9 Wild Type is supplied frozen in PBS pH 7.2, 10 % glycerol.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Product Type:
    Recombinant Protein
  • Research Area:
    Metabolism
  • Short Description:

    CircuLex PCSK9 Wild Type.

  • Size:
    50 µg
  • Storage Temperature:
    -70°C
References
  1. Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M (2003) Proc Natl Acad Sci USA 100:928–933.
  2. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, et al. (2003) Nat Genet 34:154–156.
  3. Leren TP (2004) Clin Genet 65:419–422.
  4. Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP, Fredenrich A, et al. (2005) Hum Mutat 26:497.
  5. Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264–1272.
  6. Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094–1100.
  7. Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100–7105.
  8. Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD (2005) Proc Natl Acad Sci USA 102:5374–5379.
  9. Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995–3005 10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum. Mol. Genet. 15, 1551–1558
  10. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602–18612
  11. Hyock Joo Kwon*, Thomas A. Lagace†, Markey C. McNutt†, Jay D. Horton†‡, and Johann Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820–1825.