Anti-S100P pAb

  • Applications
    • ELISA
    • WB
  • Target S100P
  • Host Species Rabbit
  • Species Reactivities Human
  • Code # CY-P1028
  • Size 50 µg
  • Price
    $289.63
Specifications

Background

Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. The calgranulins are S100 proteins that are expressed in neutrophils, and are abundant in infiltrating monocytes and granulocytes under conditions of chronic inflammation. S100P was originally described as a placental protein of 95 amino acid residues shares about 50% sequence identity with the brain S100 proteins alpha and beta. S100 proteins are small dimeric members of the EF-hand superfamily of Ca2+ binding proteins thought to participate in mediating intracellular Ca2+ signals by binding to and thereby regulating target proteins in a Ca2+-dependent manner. S100P is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, and PC3 and may play a role in the etiology of prostate cancer. In ductal hyperplasias, in situ and invasive ductal carcinoma, but not in the normal tissues, S100P overexpression is an early event that might play an important role in the immortalization of human breast epithelial cells in vitro and tumor progression in vivo. It has been known that S100P is RAGE ligand and that S100P might act in an autocrine manner via RAGE to stimulate cell proliferation and survival.
  • Antibody Type:
    Polyclonal
  • Application:
    ELISA, WB
  • Concentration:
    1.0 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Polyclonal Antibody of 50 µg targeting S100P for ELISA, WB.

  • Formulation:
    Supplied in 20mM phosphatase buffer (pH 7.5), 300mM NaCl, 50% glycerol.
  • Host Species:
    Rabbit
  • Immunogen:
    Recombinant human S100P-producing Escherichia coli
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Research Area:
    Cancer
  • Short Description:

    Anti-S100P Polyclonal Antibody.

  • Size:
    50 µg
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    S100P
References
  1. (Gribenko A, Lopez MM, Richardson JM 3rd, Makhatadze GI. : Cloning, overexpression, purification, and spectroscopic characterization of human S100P. Protein Sci. 7(1): 211-5, 1998
  2. Sato N, Hitomi J. S100P expression in human esophageal epithelial cells: Human esophageal epithelial cells sequentially produce different S100 proteins in the process of differentiation. Anat Rec. 267(1): 60-9, 2002
  3. Shyu RY, Huang SL, Jiang SY. : Retinoic acid increases expression of the calcium-binding protein S100P in human gastric cancer cells. J Biomed Sci. 10(3): 313-9, 2003
  4. Arumugam T, Simeone DM, Schmidt AM, Logsdon CD. : S100P stimulates cell proliferation and survival via RAGE. J Biol Chem. 2003 Nov 14
  5. Jin G, Wang S, Hu X, Jing Z, Chen J, Ying K, Xie Y, Mao Y. : Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+binding protein. Mol Biol Rep. 30(4): 243-8, 2003