Anti-S100A11 mAb

  • Applications
    • ELISA
    • WB
  • Target S100A11
  • Host Species Mouse
  • Species Reactivities Human
  • Code # CY-M1037
  • Size 100 μg
  • Price

Alternative Names

S100C, calgizarrin


S100A11 (S100C, cal gizarrin) is a member of the S100 family of EF-hand Ca2+-binding proteins, which is expressed in smooth muscle and other tissues. It is also localized in the cytoplasm in resting cells and moves to the cell periphery in cultured epidermal keratinocytes fol lowing calcium challenge. This movement requires the presence of intact microtubules. S100A11 was shown to bind to annexin A1 and the S100A11/annexin A1 complex is a heterotetramer consisting of two S100A11 and two annexin I proteins. Ca2+ binding to S100A11 induces a conformational change that exposes a hydrophobic surface or interaction with target proteins. S100A11 was also shown to interact with annexin A6 in Ca2+-dependent manner.
  • Antibody Type:
  • Application:
  • Clone Number:
  • Concentration:
    1.0 μg/μL
  • Conjugate:
  • Description:

    Monoclonal Antibody of 100 μg targeting S100A11 for ELISA, WB.

  • Formulation:
    1.0 mg/mL in 20 mM Phosphate Buffer/300 mM NaCl/50% glycerol, pH 7.5
  • Host Species:
  • Immunogen:
    Recombinant human S100A11
  • Isotype:
  • Product Type:
  • Research Area:
    Cell Biology
  • Short Description:

    Anti-S100A11 Monoclonal Antibody.

  • Size:
    100 μg
  • Species Reactivity:
  • Storage Temperature:
  • Target:
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  2. Donato, R.; Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type.  Biochim. Biophys. Acta 1450, 191-231, 1999 Donato, R.; S100: a multigenic family of calcium-modulated proteins of the EF-hand type with  intracellular and extracellular functional roles. Int. J. Biochem. Cell Biol. 33:637-668, 2001 
  3. Stulík J, Österreicher J, Koupilová K, Knížek J,  Bureš J, Jandík P, Langr F, DědičK, Schäfer BW,  Heizmann CW.; Differential expression of the Ca2+ binding S100A6 protein in normal,  preneoplastic and neoplastic colon mucosa. Eur. J.  Cancer 36, 1050-1059, 2000 
  4. Seth A, Lee BK, Qi S, Vary CP.; Coordinate expression of novel genes during osteoblast  differentiation. J. Bone Miner. Res. 15, 1683-1696, 2000 
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  6. Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R. Molecular cloning of the cDNA for  a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. J. Biol.  Chem. 261, 12628-12632, 1986 
  7. Calabretta B, Venturelli D, Kaczmarek L, Narni F, Talpaz M, Anderson B, Beran M, Baserga R.; Altered expression of G1-specific genes in human ma lignant myeloid cells. Proc Natl Acad Sci U S A. 83, 1495-1498, 1986 
  8. Okazaki K, Niki I, Iino S, Kobayashi S, Hidaka H ; A role of calcyclin, a Ca2+-binding protein, on  Ca2+-dependent insulin release in the pancreatic  β cell. J. Biol. Chem. 269, 6149-6152, 1994 
  9. Thordarson, G., Southard, J.N., Talamantes, F.; Purification and characterization of mouse  decidual calcyclin: A novel stimulator of mouse pla cental lactogen-II secretion Endocrinology 129,  1257-1265, 1991 
  10. Boom A, Pochet R, Authelet M, Pradier L, Borghgraef P, Van Leuven F, Heizmann CW, Brion  J-P. ; Astrocytic calcium/zinc binding protein S100 A6 over expression in alzheimer's disease and  in PS1/APP transgenic mice models. Biochim. Biophys. Acta 1742, 161-168, 2004 
  11. Hoyaux D., Boom A., Van den Bosch L., Belot N., Martin J.J., Heizmann C.W., Kiss R., Pochet  R.; S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients. J. Neuropathol. Exp. Neurol. 61, 736-744, 2002