CircuLex PCSK9-LDLR in vitro Binding Assay Kit

CircuLex PCSK9-LDLR in vitro Binding Assay Kit.

Specifications:

Components

  • Microplate
  • Recombinant His-tagged PCSK9 wild type
  • Biotinylated anti-His-tag monoclonal antibody
  • Reaction Buffer
  • HRP-conjugated Streptavidin
  • Conjugate Dilution Buffer
  • 10X Wash Buffer
  • Substrate Reagent
  • Stop Solution

Description

The CycLex Research Product CircuLex PCSK9-LDLR in vitro Binding Assay Kit can be used for screening inhibitors of PCSK9-LDLR interaction in vitro.

Target: PCSK9-LDLR
Product Type: Kit
Size: 96 Assays
Research Area / Disease: Metabolism
Storage Temperature: 4°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Citations

  1. (Yonsei Med J 2015 Jul 29)

References

  1. Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M (2003) Proc Natl Acad Sci USA 100:928–933.
  2. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, et al. (2003) Nat Genet 34:154–156.
  3. Leren TP (2004) Clin Genet 65:419–422.
  4. Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP, Fredenrich A, et al. (2005) Hum Mutat 26:497.
  5. Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264–1272.
  6. Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094–1100.
  7. Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100–7105.
  8. Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD (2005) Proc Natl Acad Sci USA 102:5374–5379.
  9. Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995–3005
  10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum. Mol. Genet. 15, 1551–1558
  11. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602–18612
Code CY-8150
Product Type Kit
Size 96 Assays
Price
$593.74
Qty:

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