Products Research Area/Disease Metabolism CircuLex PCSK9-LDLR in vitro Binding Assay Kit
CircuLex PCSK9-LDLR in vitro Binding Assay Kit
CircuLex PCSK9-LDLR in vitro Binding Assay Kit.

Specifications:
Description
The CycLex Research Product CircuLex PCSK9-LDLR in vitro Binding Assay Kit can be used for screening inhibitors of PCSK9-LDLR interaction in vitro.
Target: | PCSK9-LDLR |
---|---|
Product Type: | Kit |
Size: | 96 Assays |
Research Area / Disease: | Metabolism |
Storage Temperature: | 4°C |
Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
Components
- Microplate
- Recombinant His-tagged PCSK9 wild type
- Biotinylated anti-His-tag monoclonal antibody
- Reaction Buffer
- HRP-conjugated Streptavidin
- Conjugate Dilution Buffer
- 10X Wash Buffer
- Substrate Reagent
- Stop Solution
Citations
- (Yonsei Med J 2015 Jul 29)
References
- Momtazi-Borojeni, Amir Abbas, et al. “Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats.” Journal of Diabetes Research 2021 (2021).
- Momtazi-Borojeni, Amir Abbas, et al. “PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis.” Archives of Medical Science: AMS 17.5 (2021): 1365.
- Momtazi-Borojeni, Amir Abbas, et al. “Pre-clinical evaluation of the nanoliposomal antiPCSK9 vaccine in healthy non-human primates.” Vaccines 9.7 (2021): 749.
- Oleaga, Carlota, et al. “Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9.” Journal of lipid research 62 (2021).
- Momtazi-Borojeni, Amir Abbas, et al. “Effects of immunisation against PCSK9 in mice bearing melanoma.” Archives of Medical Science 16.1 (2020): 189-199.
- Mikaeeli, Sepideh, et al. “Functional analysis of natural PCSK 9 mutants in modern and archaic humans.” The FEBS Journal 287.3 (2020): 515-528.
- Momtazi-Borojeni, Amir Abbas, et al. “Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis.” BMC medicine 17.1 (2019): 1-15.
- Momtazi-Borojeni, Amir Abbas, et al. “Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system.” Atherosclerosis 283 (2019): 69-78.
- Momtazi-Borojeni, Amir Abbas, et al. “Potential anti-tumor effect of a nanoliposomal antiPCSK9 vaccine in mice bearing colorectal cancer.” Archives of Medical Science 15.3 (2019): 559-569.
- Ben Djoudi Ouadda, Ali, et al. “Ser-phosphorylation of PCSK9 (proprotein convertase subtilisin-kexin 9) by Fam20C (family with sequence similarity 20, member C) kinase enhances its ability to degrade the LDLR (low-density lipoprotein receptor).” Arteriosclerosis, thrombosis, and vascular biology 39.10 (2019): 1996-2013.
- Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602–18612
- Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264–1272.
- Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum. Mol. Genet. 15, 1551–1558
- Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094–1100.
- Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264–1272.
- Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995–3005
- Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP, Fredenrich A, et al. (2005) Hum Mutat 26:497.
- Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD (2005) Proc Natl Acad Sci USA 102:5374–5379.
- Leren TP (2004) Clin Genet 65:419–422.
- Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100–7105.
- NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M (2003) Proc Natl Acad Sci USA 100:928–933.
- Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, et al. (2003) Nat Genet 34:154–156.
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