CircuLex Human Progranulin ELISA Kit

This Kit is used for the quantitative measurement of human progranulin.

Specifications:

Components

  • Microplate
  • 10X Wash Buffer
  • Dilution Buffer
  • Human Progranulin Standard
  • HRP conjugated Detection Antibody
  • Substrate Reagent
  • Stop Solution

Description

This Kit is used for the quantitative measurement of human progranulin in serum, plasma, cell culture supernatant and other biological media.serum, plasma, cell culture supernatant and other biological media.

Target: Progranulin
Product Type: ELISA Kit
Size: 96 Assays
Application: ELISA
Research Area / Disease: Cancer
Species Reactivity: Human
Gene ID Human:

2896

Sensitivity: better than 20.4 pg/mL of sample.
Measurement Range: 62.5 pg/mL to 4,000 pg/mL
Storage Temperature: 4°C
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

References

  1. Daniels R, Daniels E, He Z, and Bateman A. Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development. Developmental Dynamics, vol. 227, no. 4, pp. 593–599, 2003.
  2. He Z and Bateman A. Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. Journal of Molecular Medicine, vol. 81, no. 10, pp. 600–612, 2003.
  3. Bhandari V., Palfree R. G., Bateman A. (1992) Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc. Natl. Acad. Sci. U.S.A. 89, 1715–1719
  4. Daniel R., He Z., Carmichael K. P., Halper J., Bateman A. (2000) Cellular localization of gene expression for progranulin. J. Histochem. Cytochem. 48, 999–1009
  5. Daniel R., Daniels E., He Z., Bateman A. (2003) Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development. Dev. Dyn. 227, 593–599
  6. Mackenzie I. R., Baker M., Pickering-Brown S., Hsiung G. Y., Lindholm C., Dwosh E., Gass J., Cannon A., Rademakers R., Hutton M., Feldman H. H. (2006) The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene. Brain 129, 3081–3090
  7. Matsubara T., Mita A., Minami K., Hosooka T., Kitazawa S., Takahashi K., Tamori Y., Yokoi N., Watanabe M., Matsuo E., Nishimura O., Seino S. (2012) PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab. 15, 38–50
  8. Baker M., Mackenzie I. R., Pickering-Brown S. M., Gass J., Rademakers R., Lindholm C., Snowden J., Adamson J., Sadovnick A. D., Rollinson S., Cannon A., Dwosh E., Neary D., Melquist S., Richardson A., Dickson D., Berger Z., Eriksen J., Robinson T., Zehr C., Dickey C. A., Crook R., McGowan E., Mann D., Boeve B., Feldman H., Hutton M. (2006) Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442, 916–919
  9. Cruts M., Gijselinck I., van der Zee J., Engelborghs S., Wils H., Pirici D., Rademakers R., Vandenberghe R., Dermaut B., Martin J. J., van Duijn C., Peeters K., Sciot R., Santens P., De Pooter T., Mattheijssens M., Van den Broeck M., Cuijt I., Vennekens K., De Deyn P. P., Kumar-Singh S., Van Broeckhoven C. (2006) Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442, 920–924
  10. Shankaran S. S., Capell A., Hruscha A. T., Fellerer K., Neumann M., Schmid B., Haass C. (2008) Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. J. Biol. Chem. 283, 1744–1753
  11. Tolkatchev D, Malik S, Vinogradova A. et al. Structure dissection of human progranulin identifies well-folded granulin/ epithelin modules with unique functional activities. Protein Science, vol. 17, no. 4, pp. 711–724, 2008.
  12. Boss’u P, Salani F, Alberici A et al. Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients. Journal of Neuroinflammation, vol. 8, article 65, 2011.
  13. Finch N, Baker M, Crook R. et al. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Brain, vol. 132, no. 3, pp. 583–591, 2009.
  14. Tang W, Lu Y, Tian QY. et al. The growth factor progranulin binds to tnf receptors and is therapeutic against inflammatory arthritis in mice. Science, vol. 332, no. 6028, pp. 478–484, 2011.
  15. Youn BS, Bang SI, Klöting N. et al. Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue. Diabetes, vol. 58, no. 3, pp. 627-636, 2009.
  16. Tönjes A, Fasshauer M, Kratzsch J, Stumvoll M, and M. Bluher M. Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes. PLoS One, vol. 5, no.11, Article ID e13911, 2010
Code CY-8101
Product Type ELISA Kit
Size 96 Assays
Application ELISA
Price
$595.00
Qty: