Products Research Area/Disease CircuLex Human YKL-39 ELISA Kit

CircuLex Human YKL-39 ELISA Kit

CircuLex Human YKL-39 ELISA Kit.

Specifications:

Description

The CycLex Research Product CircuLex Human YKL-39 ELISA Kit is used for the quantitative measurement of human YKL-39 in serum, plasma, cell culture medium and other biological media.

Target:	YKL-39
Product Type:	ELISA Kit
Size:	96 Assays
Application:	ELISA
Research Area / Disease:	Neuroscience
Species Reactivity:	Human
Sensitivity:	better than 35.1 pg/mL of sample.
Measurement Range:	37.5 pg/mL~2400 pg/mL
Regulatory Statement:	For Research Use Only. Not for use in diagnostic procedures.

Components

Microplate
10X Wash Buffer
Dilution Buffer
Human YKL39 Standard
HRP conjugated Detection Antibody
Substrate Reagent
Stop Solution

Citations

Petrzˇalka M, Meluzı´nova´ E, Libertı´nova´ J,Mojzˇisˇova´ H, Hanzalova´ J, Ročkova´ P, et al. IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple sclerosis. PLoS ONE17(6)(2022): e0270607.
Costa, Júlia, et al. “Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis.” Diagnostics 11.7 (2021): 1210.
Gray, Elizabeth, et al. “CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis.” Annals of clinical and translational neurology 7.8 (2020): 1296-1306.
Thompson, Alexander G., et al. “CSF chitinase proteins in amyotrophic lateral sclerosis.” Journal of Neurology, Neurosurgery & Psychiatry 90.11 (2019): 1215-1220.

References

Areshkov, PA. and Kavsan, VM. 2010. Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells. Tsitol Genet., 44: 3.
V. Dmitrenko, V. Boyko, O. et al. 2008.Overexpression of YKL-39 Gene in Glial Brain Tumors. Scholarly Research Exchange, 2008, Article ID: 814849, doi:10.3814/2008/814849.
Funkhouser, J.D. and Aronson, NN. 2007. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol. Biol., 7: 96.
Kzhyshkowska, J., Gratchev, A. and Goerdt, S. 2007. Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer. Biomarker Insights, 2: 128.
Knorr, T. Obermayr, F. Bartnik, E. Zien, A. Aigner, T. 2003. YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. Ann Rheum Dis., 62: 995.
Tsuruha, J. Masuko-Hongo, K. Kato, T. et al. 2002. Autoimmunity against YKL-39, a human cartilage derived protein, in patients with osteoarthritis. J. Rheumatol., 29: 1459.
Steck, E. Breit, S. Breusch, S.J. et al. 2002. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem. Biophys. Res. Commun., 299: 109.
Sekine, T. Masuko-Hongo, K. Matsui, T. et al. 2001. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann. Rheum. Dis., 60: 49.
Hu, B. Trinh, K. Figueira, WF. Price, PA. 1996. Isolation and sequence of a novel human chondrocyte protein to mammalian members of the chitinase protein family. J Biol Chem., 271: 19415.