CircuLex Human YKL-39 ELISA Kit

CircuLex Human YKL-39 ELISA Kit.



The CycLex Research Product CircuLex Human YKL-39 ELISA Kit is used for the quantitative measurement of human YKL-39 in serum, plasma, cell culture medium and other biological media.

Target: YKL-39
Product Type: ELISA Kit
Size: 96 Assays
Application: ELISA
Research Area / Disease: Neuroscience
Species Reactivity: Human
Sensitivity: better than 35.1 pg/mL of sample.
Measurement Range: 37.5 pg/mL~2400 pg/mL
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.


  • Microplate
  • 10X Wash Buffer
  • Dilution Buffer
  • Human YKL39 Standard
  • HRP conjugated Detection Antibody
  • Substrate Reagent
  • Stop Solution


  1. Petrzˇalka M, Meluzı´nova´ E, Libertı´nova´ J,Mojzˇisˇova´ H, Hanzalova´ J, Ročkova´ P, et al.  IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple sclerosis. PLoS ONE17(6)(2022): e0270607.
  2. Costa, Júlia, et al. “Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis.” Diagnostics 11.7 (2021): 1210.
  3. Gray, Elizabeth, et al. “CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis.” Annals of clinical and translational neurology 7.8 (2020): 1296-1306.
  4. Thompson, Alexander G., et al. “CSF chitinase proteins in amyotrophic lateral sclerosis.” Journal of Neurology, Neurosurgery & Psychiatry 90.11 (2019): 1215-1220.



  1.  Areshkov, PA. and Kavsan, VM. 2010. Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells. Tsitol Genet., 44: 3.
  2. V. Dmitrenko, V. Boyko, O. et al. 2008.Overexpression of YKL-39 Gene in Glial Brain Tumors. Scholarly Research Exchange, 2008, Article ID: 814849, doi:10.3814/2008/814849.
  3. Funkhouser, J.D. and Aronson, NN. 2007. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol. Biol., 7: 96.
  4. Kzhyshkowska, J., Gratchev, A. and Goerdt, S. 2007. Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer. Biomarker Insights, 2: 128.
  5. Knorr, T. Obermayr, F. Bartnik, E. Zien, A. Aigner, T. 2003. YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. Ann Rheum Dis., 62: 995.
  6. Tsuruha, J. Masuko-Hongo, K. Kato, T. et al. 2002. Autoimmunity against YKL-39, a human cartilage derived protein, in patients with osteoarthritis. J. Rheumatol., 29: 1459.
  7. Steck, E. Breit, S. Breusch, S.J. et al. 2002. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem. Biophys. Res. Commun., 299: 109.
  8. Sekine, T. Masuko-Hongo, K. Matsui, T. et al. 2001. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann. Rheum. Dis., 60: 49.
  9. Hu, B. Trinh, K. Figueira, WF. Price, PA. 1996. Isolation and sequence of a novel human chondrocyte protein to mammalian members of the chitinase protein family. J Biol Chem., 271: 19415.
Code CY-8087
Product Type ELISA Kit
Size 96 Assays
Application ELISA