CircuLex S100P ELISA Kit

  • Applications
    • ELISA
  • Code # CY-8060
  • Size 96 Assays
  • Price
    $593.74
Specifications

Background

Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. One of the least studied members of the S100 family is S100P, a 95-amino acid protein first purified from placenta with a restricted cellular distribution (1, 2). The molecular structure of S100P has been well described and supports its classification in the S100 family of proteins (3). Expression of S100P has been noted in esophageal epithelial cells during their differentiation, indicating that it may play a role in normal development (4). There is also considerable evidence that S100P plays a role in cancer. S100P expression has been noted in various cancer cell lines including breast cancer, where it was associated with cellular immortalization (5), and colon cancer, where its expression was elevated in doxorubicin-resistant cells (6). S100P has also been shown to be expressed in tumors, including prostate cancer, where its expression is androgen-sensitive (7), and pancreatic adenocarcinoma, where expression has been localized to the neoplastic epithelium of pancreatic (8). Furthermore, S100P expression has been shown to be correlated with decreased survival in patients with lung cancer (9).
  • Application:
    ELISA
  • Components:
    • Microplate
    • 10X Wash Buffer
    • Dilution Buffer
    • Human S100P Standard
    • HRP conjugated Detection Antibody
    • Substrate Reagent
    • Stop Solution
  • Description:

    The CircuLex S100P ELISA Kit is used for the quantitative measurement of S100P in cell lysate, cell culture conditioned medium, serum, plasma and other biological media. It can be used for 96 Assays.

  • Product Type:
    ELISA Kit
  • Research Area:
    Metabolism
  • Short Description:

    CircuLex S100P ELISA Kit.

  • Size:
    96 Assays
Citations
  1. Mori Y et al. A minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma using biomarkers in duodenal juice. Pancreas. 42, 187-92 (2013),
  2. Saito T et al. Distinct expression patterns of alveolar "alarmins" in subtypes of chronic lung allograft dysfunction. Am J Transplant. 14, 1425-32 (2014),
  3. Sato Y et al. Clinicopathological significance of S100 protein expression in cholangiocarcinoma. J Gastroenterol Hepatol. 28, 1422-9 (2013)
References
  1. Becker, T., Gerke, V., Kube, E., and Weber, K. (1992) Eur. J. Biochem. 207, 541–547
  2. Emoto, Y., Kobayashi, R., Akatsuka, H., and Hidaka, H. (1992) Biochem. Biophys. Res. Commun. 182, 1246–1253
  3. Zhang, H., Wang, G., Ding, Y., Wang, Z., Barraclough, R., Rudland, P. S., Fernig, D. G., and Rao, Z. (2003) J. Mol. Biol. 325, 785–794
  4. Sato, N., and Hitomi, J. (2002) Anat. Rec. 267, 60–69
  5. Guerreiro, D. S., I, Hu, Y. F., Russo, I. H., Ao, X., Salicioni, A. M., Yang, X., and Russo, J. (2000) Int. J. Oncol. 16, 231–240
  6. Bertram, J., Palfner, K., Hiddemann, W., and Kneba, M. (1998) Anticancer Drugs 9, 311–317
  7. Averboukh, L., Liang, P., Kantoff, P. W., and Pardee, A. B. (1996) Prostate 29, 350–355
  8. Logsdon, C. D., Simeone, D. M., Binkley, C., Arumugam, T., Greenson, J. K., Giordano, T. J., Misek, D. E., and Hanash, S. (2003) Cancer Res. 63, 2649–2657
  9. Beer, D. G., Kardia, S. L., Huang, C. C., Giordano, T. J., Levin, A. M., Misek, D. E., Lin, L., Chen, G., Gharib, T. G., Thomas, D. G., Lizyness, M. L., Kuick, R., Hayasaka, S., Taylor, J. M., Iannettoni, M. D., Orringer, M. B., and Hanash, S. (2002) Nat. Med. 8, 816–824