CycLex® Phospho-p62 Ser403 ELISA Kit

  • Applications
    • ELISA
  • Target Phospho-p62 Ser403
  • Code # CY-7057
  • Size 96 Assay
  • Price
    $669.03
Specifications

Alternative Names

sequestosome 1, p60, p62, A170, OSIL, PDB3, ZIP3, p62B/Osi, A170, STAP, OSF-6/Osi, ZIP

Background

The phosphorylation of p62 modifies the affinity of domain for target protein. The phosphorylation of p62 on serine 403 (human)/serine 405 (mouse) in UBA domain, which is phosphorylated by casein kinase 2 and/or TANK-binding kinase 1, promotes its translocation to ubiquitinated proteins, and which progresses selective autophagic clearance of ubiquitinated proteins aggregates. On the other hand, phosphorylation of p62 on serine 349 (human)/serine 351 (mouse) in KIR motif, which is phosphorylated by mTORC1 in vitro, enhances its affinity for Keap1, and which follows selective autophagy of Keap1, leading to Nrf2 activation. mTORC1 interacts with p62 via raptor and phosphorylates serine 349 (human)/serine 351 (mouse) of p62, which is required for mTORC1 activation in response to amino acids and is shown to be a nice marker of the activation of mTORC1 in autophagy pathways.
  • Application:
    ELISA
  • Description:
    The MBL Research Product CycLex Phospho-p62 Ser403 ELISA Kit is used for the semi-quantitative measurement of phosphorylated p62 proteins at serine 403 in human cell lysate or serine405 in mouse cell lysate.
  • Product Type:
    ELISA Kit
  • Sensitivity:
    0.73 AU/mL~
  • Size:
    96 Assay
  • Storage Temperature:
    4°C
  • Target:
    Phospho-p62 Ser403