cycLex PDK1 Kinase Assay/Inhibitor Screening Kit-Discontinued (Discontinued)



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  1. Daisuke Tamura, Tokuzo Arao, Kaoru Tanaka, Hiroyasu Kaneda, Kazuko Matsumoto, Kanae Kudo, Keiichi Aomatsu, Yoshihiko Fujita, Takashi Watanabe, Nagahiro Saijo, Yoshikazu Kotani, Yoshihiro Nishimura, and Kazuto Nishio; Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition. Cancer Science 101: 1403-1408, 2010,
  2. Deng Q et al. Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell Death Dis. 4, e804 (2013),
  3. Jai-Sing Yang, Mann-Jen Hour, Wen-Wen Huang, Kuei-Li Lin, Sheng-Chu Kuo, and Jing-Gung Chung; MJ-29 Inhibits Tubulin Polymerization, Induces Mitotic Arrest, and Triggers Apoptosis via Cyclin-Dependent Kinase 1-Mediated Bcl-2 Phosphorylation in Human Leukemia U937 Cells. J. Pharmacol. Exp. Ther. 334: 477 _ 488, 2010,
  4. Kravtsov D et al. Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Am J Physiol Gastrointest Liver Physiol. 307, G992-G1001 (2014),
  5. Mashukova A, Wald FA, Salas PJ.; Tnf-{alpha} and inflammation disrupt the polarity complex in intestinal epithelial cells by a post-translational mechanism. Mol Cell Biol., 31:756-65. 2011,
  6. Mashukova A, Wald FA, Salas PJ.; Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mol Cell Biol. 31: 756-65, 2011


  1. Toker A, and Newton AC (2000) Cellular signaling: pivoting around PDK-1. Cell 103: 185–188
  2. Mora A, Komander D, van Aalten DMF, Alessi DR (2004) PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15: 161–170
  3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261–269
  4. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (1998) Protein kinase B kinases that
  5. mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279: 710–714
  6. Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J (1999) Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J 337 (Part 3): 575–583
  7. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70: 535–602
  8. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D. et al. (1997) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7, 776–789
  9. Pullen, N., Dennis, P. B., Andjelkovi, M., Dufner, A., Kozma, S. C., Hemmings, B. A. and Thomas, G. (1998) Phosphorylation and activation of p70s6k by PDK1. Science 279, 707–710
  10. Casamayor, A., Morrice, N. and Alessi, D. R. (1999) Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase 1: identification of five sites of phosphorylation in vivo. Biochem. J. 342, 287–292
  11. Anderson, K. E., Coadwell, J., Stephens, L. R. and Hawkins, P. T. (1998) Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol. 8, 684–691
  12. Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R. and Lucocq, J. (1999) Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337, 575–583
  13. Hanada, M., Feng, J., and Hemmings, B. A. (2004) Biochim. Biophys. Acta 1697, 3-16
  14. Shiojima, I., and Walsh, K. (2002) Circ. Res. 90, 1243-1250
Code cy-1180
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