Products Research Area/Disease Cancer CycLex® IKKα and β Kinase Assay/Inhibitor Screening Kit

CycLex® IKKα and β Kinase Assay/Inhibitor Screening Kit (Discontinued)

CycLex IKKα/β Kinase Assay/Inhibitor Screening Kit.

Specifications:

Description

We are sorry for the inconvenience; this product code has been discontinued.

The CycLex Research Products IKK α/β assay/Inhibitor Screening Kit is designed to measure the activities of purified IKKα and IKKβ for the rapid and sensitive evaluation of inhibitors or activators. It can be used for 96 Assays.

Target:	IKKα and β Kinase
Product Type:	Kinase Assay Kit
Size:	96 Assays
Research Area / Disease:	Cancer
Regulatory Statement:	For Research Use Only. Not for use in diagnostic procedures.

Components

Microplate
10X Wash Buffer
Kinase Buffer
20X ATP
Anti-Phospho-IkappaBbeta S32 Monoclonal Antibody (AS-2E8)
HRP conjugated Anti-mouse IgG
Substrate Reagent
Stop Solution

Citations

Fakhrudin N et al. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Br J Pharmacol. 171, 1676-86 (2014),
Harada S, Tominari T, Matsumoto C, Hirata M, Takita M, Inada M, Miyaura C.; Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency. J Pharmacol Sci. 115: 89-93, 2011,
Heyninck K et al. Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ. Biochem Pharmacol. 91, 501-9 (2014),
Qiu J et al. Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism. Proc Natl Acad Sci U S A. 110, 18162-7 (2013)
Hirata N et al. Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity. Nutrients. 11, pii: E368 (2019)

References

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