CycLex® p38 Kinase Assay/Inhibitor Screening Kit

CycLex p38 Kinase Assay/Inhibitor Screening Kit.

Specifications:

Description

CycLex p38 Kinase Assay/Inhibitor Screening Kit.

Target: p38
Product Type: Kinase Assay Kit
Size: 96 Assays
Research Area / Disease: Cell Biology
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

Components

  • Microplate
  • 10X Wash Buffer
  • Kinase Buffer
  • 20X ATP
  • Anti-Phospho-ATF2 Thr71 Polyclonal Antibody (PPT-08)
  • HRP conjugated Anti-rabbit IgG
  • Substrate Reagent
  • Stop Solution

Citations

  1. Lin S et al. Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation. Mol Nutr Food Res. 57, 1135-44 (2013)

References

  1. English J, Pearson G, Wilsbacher J, et al. New insights into the control of MAP kinase pathways. Exp Cell Res. 1999; 253: 255-270.
  2. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu. Rev. Immunol. 2002; 20: 55-72
  3. Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994; 265: 808-811
  4. Chan-Hui, P. Y. and Weaver, R. (1998). Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. Biochem. J. 336,599 -609
  5. Stein B, Yand MX, Young DB, et al. p38–2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997; 272: 19509-19517
  6. Jiang Y, Chen C, Lie Z, et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J Biol Chem. 1996; 271: 17920-179267) 7) Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 1997; 9:180-186.
  7. Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998; 273: 1741-1748
  8. Lee JC, Laydon JT, McDonnell PC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994; 372: 739-746
Code CY-1177
Product Type Kinase Assay Kit
Size 96 Assays
Price
$654.60
Qty: