CycLex® c-Src Kinase Assay/Inhibitor Screening Kit

CycLex c-Src Kinase Assay/Inhibitor Screening Kit.



  • Microplate
  • 10X Wash Buffer
  • Kinase Buffer
  • 20X ATP
  • HRP conjugated Detection Antibody
  • Substrate Reagent
  • Stop Solution


The CycLex Research Product c-Src Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of c-Src for the rapid and sensitive evaluation of inhibitors or activators. It can be used for 96 assays.

Target: c-Src
Product Type: Kinase Assay Kit
Size: 96 Assays
Research Area / Disease: Cell Biology
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.


  1. Al-Wadei MH et al. Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. Cancer Prev Res. 6, 139-48 (2013),
  2. Kang Y et al. Anti-angiogenic activity of macrolactin A and its succinyl derivative is mediated through inhibition of class I PI3K activity and its signaling. Arch Pharm Res. 38, 249-60 (2015),
  3. Takuma Matsubara, Fumiyo Ikeda, Kenji Hata, Masako Nakanishi, Masato Okada, Hisataka Yasuda, Riko Nishimura, Toshiyuki Yoneda; Cbp Recruitment of Csk Into Lipid Rafts is Critical to c-Src Kinase Activity and Bone Resorption in Osteoclasts. Journal of Bone and Mineral Research, 25: 1068-1076, 2010
  4. Gautam J et al. Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis. Exp Mol Med. 50, 118 (2018)


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  3. Brickell, P. M. The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. Crit. Rev. Oncog., 3: 401–446, 1992
  4. Collett, M. S., Brugge, J. S., and Erikson, R. L. Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product. Cell, 15:1363–1369, 1978
  5. Summy JM, Gallick GE. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev. 22(4):337-58, 2003
  6. Guy, C. T., Muthuswamy, S. K., Cardiff, R. D., Soriano, P., and Muller, W. J. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev., 8: 23–32, 1994
  7. Irby, R. B.; Mao, W.; Coppola, D.; Kang, J.; Loubeau, J. M.; Trudeau, W.; Karl, R.; Fujita, D. J.; Jove, R.; Yeatman, T. J. : Activating SRC mutation in a subset of advanced human colon cancers. Nature Genet. 21: 187-190, 1999
Code CY-1083
Product Type Kinase Assay Kit
Size 96 Assays