cycLex FGFR2 Kinase Assay/Inhibitor Screening Kit-Discontinued



This product has been discontinued.

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  1. Herbert C et al. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell. 23, 489-501 (2013)


  1. Fibroblast growth factors David M Ornitz and Nobuyuki Itoh. Genome Biology 2 : reviews 3005.1-3005.12, 2001
  2. Johnson D, Williams L: Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 60:1-41, 1993
  3. Plontnikov A, Schlessinger J, Hubbard S, Mohammadi M: Structural basis of fgf receptor dimerization and activation. Cell 98:641-650, 1999
  4. Luqmani Y, Graham M, Coombes R: Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues. Br J Cancer 1992, 66:271–280. 1992
  5. Adnane J, Gaudray P, Dionne C, et al: BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. Oncogene 6:659–663, 1991
  6. Penault-Llorca F, Bertucci F, Adelaide J: Expression of FGF and FGF receptor genes in human breast cancer. Int J Cancer 61:170–176, 1991
  7. Preston, R. A.; Post, J. C.; Keats, B. J. B.; Aston, C. E.; Ferrell, R. E.; Priest, J.; Nouri, N.; Losken, H. W.; Morris, C. A.; Hurtt, M. R.; Mulvihill, J. J.; Ehrlich, G. D. : A gene for Crouzon craniofacial dysostosis maps to the long arm of chromosome 10. Nature Genet. 7: 149-153, 1994
  8. Jabs, E. W.; Li, X.; Scott, A. F.; Meyers, G.; Chen, W.; Eccles, M.; Mao, J.; Charnas, L. R.; Jackson, C. E.; Jaye, M. : Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nature Genet. 8: 275-279, 1994
  9. Reardon, W.; Winter, R. M.; Rutland, P.; Pulleyn, L. J.; Jones, B. M.; Malcolm, S. : Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nature Genet. 8: 98-103, 1994
  10. Wilkie, A. O. M.; Slaney, S. F.; Oldridge, M.; Poole, M. D.; Ashworth, G. J.; Hockley, A. D.; Hayward, R. D.; David, D. J.; Pulleyn, L. J.; Rutland, P.; Malcolm, S.; Winter, R. M.; Reardon, W. : Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome. Nature Genet. 9: 165-172, 1995
  11. Lajeunie, E.; Ma, H. W.; Bonaventure, J.; Munnich, A.; Le Merrer, M.; Renier, D. : FGFR2 mutations in Pfeiffer syndrome. Nature Genet. 9: 108, 1995
  12. Rutland, P.; Pulleyn, L. J.; Reardon, W.; Baraitser, M.; Hayward, R.; Jones, B.; Malcolm, S.; Winter, R. M.; Oldridge, M.; Slaney, S. F.; Poole, M. D.; Wilkie, A. O. M. : Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes. Nature Genet. 9: 173-176, 1995
  13. Gorry, M. C.; Preston, R. A.; White, G. J.; Zhang, Y.; Singhal, V. K.; Losken, H. W.; Parker, M. G.; Nwokoro, N. A.; Post, J. C.; Ehrlich, G. D. : Crouzon syndrome: mutations in two spliceoforms of FGFR2 and a common point mutation shared with Jackson-Weiss syndrome. Hum. Molec. Genet. 4: 1387-1390, 1995
Code cy-1082
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