CycLex® Met Kinase Assay/Inhibitor Screening Kit

CycLex Met Kinase Assay/Inhibitor Screening Kit.

Specifications:

Components

  • Microplate
  • 10X Wash Buffer
  • Kinase Buffer
  • 20X ATP HRP conjugated Detection Antibody Substrate Reagent
  • Stop Solution

Description

The CycLex Met Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of Met for the rapid and sensitive evaluation of inhibitors or activators.

Product Type: Kinase Assay Kit
Size: 96 Assays
Research Area / Disease: Cell Biology
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.

References

  1. Cooper, C.S., et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature. 311:29–33, 1984
  2. Bottaro, D.P., et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251:802–804, 1991
  3. Schmidt, L., et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat. Genet. 16:68–73, 1997
  4. Schmidt, L., et al. Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene. 18:2343–2350, 1999
  5. Olivero, M., et al. Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family. Int. J. Cancer.82:640–643, 1999
  6. Park, W.S., et al. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res. 59:307–310, 1999
  7. Lee, J.H., et al. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene. 19:4947–4953, 2000
  8. Di Renzo, M.F., et al. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene. 19:1547–1555, 2000
  9. Comoglio, P.M., and Trusolino, L. Invasive growth: from development to metastasis. J. Clin. Invest. 109:857–862, 2002
Code CY-1080
Product Type Kinase Assay Kit
Size 96 Assays
Price
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