The MBL Bion CMV-G ANTIBODY TEST SYSTEM utilizes the indirect fluorescent antibody assay to be used with human serum.
The MBL Bion CMV-G (Cytomegalovirus) ANTIBODY TEST SYSTEM is an indirect fluorescent antibody assay for the qualitative and/or semi-quantitative determination of CMV IgG antibodies in human serum. The MBL Bion CMVG ANTIBODY TEST SYSTEM is intended for use as an aid in the diagnosis of primary infection, reinfection or reactivation of the latent virus, and also as a determination of immunological experience with CMV. This Test System is not intended for use by blood banks for blood donor screening.
Neonatal infections can be congenital or prenatal. Ninety-five percent of congenital infections, or Cytomegalovirus Inclusion Disease (CID), are asymptomatic at birth but later may manifest neurologic abnormalities. The remaining 5% have classic CID with symptoms characterized by cerebral calcification, hepatomegaly, splenomegaly, jaundice, rash, microcephaly, pneumonia, and chorioretinitis. The clinical symptoms of CID are very similar to those seen in congenital rubella, toxoplasmosis or congenital syphilis syndromes. Perinatal infection is most often caused by exposure to the virus in the birth canal. Perinatal infected infants start excreting CMV three to twelve weeks after delivery and generally remain asymptomatic.
The manifestations of symptomatic CMV infection in children and adults are similar to those of classic Epstein-Barr Virus (EBV) Infectious Mononucleosis, with fever, hepatitis, splenomegaly, lymphadenopathy, and viremia. In CMV mononucleosis syndrome, however, the heterophile is negative. CMV may be transmitted by blood transfusions and organ transplantation or reactivated by immunosuppression. There is also a high incidence of CMV in persons with acquired immune deficiency syndrome (AIDS). Individuals with primary infection of CMV or those who have had a previous experience with CMV and are experiencing a reinfection or reactivation, may be shedding infectious virus continuously or at intermittent periods and should be considered infectious to susceptible hosts.
The MBL Bion CMV-G (Cytomegalovirus) ANTIBODY TEST SYSTEM is an indirect fluorescent antibody assay for the qualitative and/or semi-quantitative determinationof CMV IgG antibodies in human serum.