Cytomegalovirus IgG Test Kit

  • Applications
    • IF
  • Code # CMG-120
  • Size 120 tests
  • Price Call for Price
Specifications

Background

Neonatal infections can be congenital or prenatal. Ninety-five percent of congenital infections, or Cytomegalovirus Inclusion Disease (CID), are asymptomatic at birth but later may manifest neurologic abnormalities. The remaining 5% have classic CID with symptoms characterized by cerebral calcification, hepatomegaly, splenomegaly, jaundice, rash, microcephaly, pneumonia, and chorioretinitis. The clinical symptoms of CID are very similar to those seen in congenital rubella, toxoplasmosis or congenital syphilis syndromes. Perinatal infection is most often caused by exposure to the virus in the birth canal. Perinatal infected infants start excreting CMV three to twelve weeks after delivery and generally remain asymptomatic.

The manifestations of symptomatic CMV infection in children and adults are similar to those of classic Epstein-Barr Virus (EBV) Infectious Mononucleosis, with fever, hepatitis, splenomegaly, lymphadenopathy, and viremia. In CMV mononucleosis syndrome, however, the heterophile is negative. CMV may be transmitted by blood transfusions and organ transplantation or reactivated by immunosuppression. There is also a high incidence of CMV in persons with acquired immune deficiency syndrome (AIDS). Individuals with primary infection of CMV or those who have had a previous experience with CMV and are experiencing a reinfection or reactivation, may be shedding infectious virus continuously or at intermittent periods and should be considered infectious to susceptible hosts.

  • Application:
    IF
  • Components:
    • CMV Substrate Slide, ten slides, twelve wells each (Code# CM-2012)
    • CMV IgG Positive Control Serum, 0.5 mL (Code# CMG-2020)
    • CMV Negative Control Serum, 0.5 mL (Code# CMN-2010)
    • Conjugate, IgG with Counterstain, 2 x 3.5 mL (Code# CCG-9972)
    • Mounting Medium, 3.5 mL (Code# MM-9985)
    • PBS Packet, 2 x 1 Liter packets (Code# PBS-9990)
  • Description:

    The MBL Bion CMV-G ANTIBODY TEST SYSTEM utilizes the indirect fluorescent antibody assay to be used with human serum. 

    INTENDED USE

    The MBL Bion CMV-G (Cytomegalovirus) ANTIBODY TEST SYSTEM is an indirect fluorescent antibody assay for the qualitative and/or semi-quantitative determination of CMV IgG antibodies in human serum. The MBL Bion CMVG ANTIBODY TEST SYSTEM is intended for use as an aid in the diagnosis of primary infection, reinfection or reactivation of the latent virus, and also as a determination of immunological experience with CMV. This Test System is not intended for use by blood banks for blood donor screening.

  • Product Type:
    Kit
  • Research Area:
    Infectious Disease
  • Short Description:

    The MBL Bion CMV-G (Cytomegalovirus) ANTIBODY TEST SYSTEM is an indirect fluorescent antibody assay for the qualitative and/or semi-quantitative determination
    of CMV IgG antibodies in human serum.

  • Size:
    120 tests
References
  1. Starr, S.E., Cytomegalovirus, Pediatr. Clin. N. Amer., 26:283-293, 1979.
  2. Reynolds, D.W., S. Stagno, C.A. Alford, Laboratory Diagnosis of Cytomegalovirus Infections, in: Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, Lennette, E.H., N.J. Schmidt (eds), APHA, Washington, D.C., 1979.
  3. Hanshaw, J.B., J.A. Dudgeon, Congenital Cytomegalovirus. Viral Diseases of the Fetus and Newborn, Saunders, Philadelphia, 1978.
  4. Hanshaw, J.B., Congenital and Acquired Cytomegalovirus Infection, Pediatr. Clin. N. Amer., 13:279-293, 1966.
  5. Nankervis, G.A., M.L. Kumar, Diseases Produced by Cytomegaloviruses, Medical Clinics of N. Amer., 62:1021-1035, 1978.
  6. Melish, M.E., J.B. Hanshaw, Congenital Cytomegalovirus Infection: Developmental Progress of Infants Detected by Routine Screening, Am. J. Dis. Child., 126:190-194, 1973.
  7. MacDonald, H., J.H. Tobin, Congenital Cytomegalovirus Infection: A Collaborative Study on Epidemiological, Clinical and Laboratory Findings, Develop. Med. Child. Neurol., 20:471-482, 1978.
  8. Stern, H., Isolation of Cytomegalovirus and Clinical Manifestations of Infections at Different Ages, Br.Med. J., 1:665-669, 1968.
  9. Evans, A.S., Infectious Mononucleosis and Related Syndromes, Am. J. Med. Sci., 276:325-339, 1978.
  10. Ho, M., Cytomegalovirus: Biology and Infection, Plenum Medical, New York, 1982.
  11. Alford, C.A., R.P. Stagno, E.S. Huang, Epidemiology of Cytomegalovirus, in: The Human Herpesviruses, Nahmias, A.J., W.R. Dowdle, R.F. Schinazi (eds), Elsevier, New York, 159-171, 1981.
  12. Stagno, S., R.F. Pass, D.W. Reynolds, C.A. Alford, Diagnosis of Cytomegalovirus Infections, in: The Human Herpesviruses, Nahmias, A.J., W.R. Dowdle, R.F. Schinazi (eds), Elsevier, New York, 363-373, 1981.
  13. Weller, T.H., A.H. Coons, Fluorescent Antibody Studies with Agents of Varicella and Herpes Zoster Propagated In Vitro, Proc. Soc. Exp. Biol. Med., 86:789-794, 1954.
  14. Riggs, J.L., R.J. Seiwald, J.H. Burckhalter, C.M. Downs, T.G. Metcalf, Isothiocyanate Compounds as Fluorescent Labeling Agents for Immune Serum, Am. J. Pathol.,  34:1081-1097, 1958.
  15. Lyerla, H.C., F.T. Forrester, The Immunofluorescence (IF) Test, in Immunofluorescence Methods in Virology, USDHHS, Georgia, 71-81, 1979.
  16. Keller, R., R. Psitchel, J.N. Goldman et al., An IgG-Fc Receptor Induced in Cytomegalovirus-Infected Human Fibroblasts, J. Immuno., 116:772-777, 1976.
  17. Holborow, E.J., D.M. Weir, G.D. Johnson, A Serum Factor in Lupus Erythematosus With Affinity for Tissue Nuclei, Br. Med. J., 11:732-734, 1957.
  18. Berg, P.A., I. Roitt, D. Doniach, H.M. Cooper, Mitochondrial Antibodies in Primary Biliary Cirrhosis, Immunol., 17:281-293, 1969.
  19. Alford, C.A., R.P. Stagno, E.S. Huang, Epidemiology of Cytomegalovirus, in: The Human Herpesviruses, Nahmias, A.J., W.R. Dowdle, R.F. Schinazi (eds), Elsevier, New York, 159-171, 1981.
  20. Chernesky, M.A., C.G. Ray, T.F. Smith, Laboratory Diagnosis of Viral Infections, Cumitech 15, ASM, Washington, D.C., March 1982.
  21. Arvin, A.M., Cytomegaloviruses, in: Laboratory Diagnosis of Viral Infections, Lennette, E.H. (ed), Marcel Dekker, New York, 225-240, 1985.
  22. Data on file, MBL Bion, Des Plaines, Illinois.
  23. Personal Communications, Ascher, M., Manager, Immunology, Virology & Microbiology Laboratories, Elmhurst Memorial Hospital, Elmhurst, Illinois