Anti-SynCAM (TSLC1/CADM1) (Human) mAb

  • Applications
    • FCM
    • ICC
    • IHC
    • IP
    • WB
  • Target SynCAM/TSLC1
  • Host Species Chicken
  • Species Reactivities Human, Mouse
  • Code # CM004-3
  • Size 100 μg
  • Price
    $389.88
Specifications

Alternative Names

CADM1

Background

SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
  • Antibody Type:
    Monoclonal
  • Application:
    FCM, ICC, IHC, IP, WB
  • Clone Number:
    30
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:
    Monoclonal antibody of 100 μg targeting SynCAM/TSLC1 for FCM, ICC, IHC, IPP, WB.
  • Formulation:
    100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
  • Gene ID (Human):
  • Gene ID (Mouse):
  • Host Species:
    Chicken
  • Immunogen:
    Recombinant fusion protein Fc-SynCAM
  • Isotype:
    IgY
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with extracellular domain of SynCAM on Flow cytometry, Western blotting, Immunoprecipitation and Immunohistochemistry.
  • Research Area:
    Neuroscience
  • Short Description:
    SynCAM/TSLC1 Monoclonal Antibody.
  • Size:
    100 μg
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
    -20°C
  • Target:
    SynCAM/TSLC1
Citations
  1. Fogel AI et al. SynCAMs organize synapses through heterophilic adhesion. J Neurosci. 27, 12516-30 (2007),
  2. Fujita E et al. Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol. 171, 1800-10 (2007),
  3. Gao Y, Lui WY. Transforming growth factor-β1 (TGF-β1) regulates cell junction restructuring via Smad-mediated repression and clathrin-mediated endocytosis of nectin-like molecule 2 (Necl-2). PLoS One 8, e64316 (2013),
  4. Hagiyama M et al. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. Am J Pathol. 174, 2278-89 (2009),
  5. Hasstedt SJ et al. Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood. 114, 3084-91 (2009),
  6. Hollins F et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 181, 2772-80 (2008),
  7. Wakayama T et al. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biol Reprod. 76, 1081-90 (2007),
  8. Yang W et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol. 176, 1238-43 (2006)
References
  1. Hagiyama, M., et al., Am. J. Pathol. 174, 2278-2289 (2009)
  2. Hasstedt, S. J., et al., Blood 114, 3084-3091 (2009)
  3. Hollins, F., et al., J. Immunol. 181, 2772-2780 (2008)
  4. Wakayama, T., et al., Biol. Reprod. 76, 1081-1090 (2007)
  5. Fogel, A. I., et al., J. Neurosci. 27, 12516-12530 (2007)
  6. Yang, W., et al., J. Immunol. 176, 1238-1243 (2006)
  7. Furuno, T., et al., J. Immunol. 174, 6934-6942 (2005)
  8. Sara, Y., et al., J. Neuroscience 25, 260-270 (2005)
  9. Biederer, T., et al., Science 297, 1525-1531 (2002)