The MBL Bion BARTONELLA HENSELAE ANTIGEN SUBSTRATE SLIDES may be utilized in the indirect fluorescent antibody assay method. Each lot is tested with a panel of titered sera to ensure sensitivity lot to lot; both positive and negative cells are in each well to provide a built-in control.
For Research Use Only
The Bartonella bacillus is a delicate, fastidious, slow-growing, aerobic, gram negative, pleomorphic rod. Members of the genus Bartonella have recently been associated with an increasing spectrum of diverse clinical syndromes ranging from only lymphadenopathy, in cat scratch disease (CSD), to systemic disease including bacillary angiomatosis (BA). Serious complications can include endocardi- tis and lesions of almost every organ system including the heart, liver, spleen, bone and bone marrow, lymphatics, muscle and soft tissue, and the central nervous system. Cat Scratch Disease (CSD) is a persistent, necrotizing inflammation of the lymph nodes affecting an estimated 24,000 persons annually. CSD occurs primarily in children and young adults usually less than 21 years of age. CSD is seasonal, with most cases predominantly in the fall and winter. This may be accounted for by having cats indoors in these seasons. The role of cats in the transmission of the agent causing CSD is well established. A patient with a history of cat contact or scratch presents with lymphadenopathy usually preceded by an erythematous papule at the inoculation site. Uncomplicated CSD usually resolves spontaneously in 2-6 months. Less often, (5-20%) patients may experience rash, hepatosplenomegaly, lytic bone lesions, granulomatous conjunctivitis, pneumonitis, endocarditis, and central nervous system involvement.
MBL Bion BARTONELLA ANTIGEN SUBSTRATE SLIDES are individually foil-wrapped six well slides with a mixture of B. henselae (Houston strain) infected and uninfected HEp-2 cells fixed onto each well. Each well contains an average of 25-30% infected cells per 200X field.