Recombinant Mouse IL-18 (without BSA) Lyoph.

  • Code # B004-2
  • Size 200 µg
  • Price
    $1,281.04
Specifications

Alternative Names

interleukin 18 (interferon-γ-inducing factor)

Background

Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-g (IFN-g) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-g is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-g activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-g also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-g. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-g and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-g in T cells, enhancement of Fas ligand expression by Th1 cells
  • Description:
    IL-18 Protein of 200 µg.
  • Formulation:
    Lyophilized in PBS containing 1%sucrose. Reconstitute in 2 mL of ice-cold distilled water onice.
  • Gene ID (Human):
  • Product Type:
    Cytokine
  • Research Area:
    Immunology
  • Short Description:
    IL-18 Protein.
  • Size:
    200 µg
  • Storage Temperature:
    -20°C. Please refer to datasheet for additional information
Citations
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