Anti-Bad (Mouse) pAb

  • Applications
    • WB
  • Target Bad
  • Host Species Rabbit
  • Species Reactivities Human, Mouse
  • Code # 591
  • Size 100 µl
  • Price
    $278.49
Specifications

Background

The Bcl-2 related genes can inhibit (Bcl-xL and Mcl-1) or induce (Bax, Bcl-xS, Bag, and Bad) apoptosis in several systems. Bad is identified as a Bcl-2 interacting protein using a yeast two hybrid screening and λ expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-xL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-xS, Mcl-1, and A1). When Bad heterodimerizes with Bcl-xL, is displaces Bac from Bcl-xL and promotes cell death.
  • Antibody Type:
    Polyclonal
  • Application:
    WB
  • Conjugate:
    Unlabeled
  • Description:
    Polyclonal antibody of 100 µl targeting Bad for WB.
  • Formulation:
    0.1 mL in PBS/50% glycerol, pH 7.2
  • Gene ID (Human):
    572
  • Gene ID (Mouse):
    12015
  • Host Species:
    Rabbit
  • Immunogen:
    Recombinant full-length mouse Bad (1-204 aa)
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with human and mouse Bad on Western blotting.
  • Research Area:
    Apoptosis
  • Short Description:
    Bad primary antibody.
  • Size:
    100 µl
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
    -20°C
  • Target:
    Bad
Citations
  1. Hirose Y et al. Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc. Natl. Acad. Sci. USA 109, 4263-4268 (2012),
  2. Nonaka H et al. Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Dev. Dyn. 236, 2258-2267 (2007),
  3. Nonaka H et al. Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling. Biochem. Biophys. Res. Commun. 375, 256-260 (2008)
References
  1. Gauthier, E. R., et al., Cancer Res. 56, 1451-1456 (1996)
  2. Yang, E., et al., Cell 80, 285-291 (1995)