Anti-CD117 (c-Kit) (Human) pAb

  • Applications
    • ICC
    • IHC
  • Target CD117
  • Host Species Rabbit
  • Species Reactivities Human
  • Code # 566-H
  • Size 6 mL
  • Price
    $139.24
Specifications

Alternative Names

KIT, PBT, SCFR

Background

c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
  • Antibody Type:
    Polyclonal
  • Application:
    ICC, IHC
  • Conjugate:
    Unlabeled
  • Description:
    Polyclonal antibody of 6 ml targeting CD117 for ICC, IHC.
  • Formulation:
    In 20 mM HEPES/1% BSA/0.135 M NaCl/0.1% sodium azide
  • Host Species:
    Rabbit
  • Immunogen:
    Synthetic peptide C-terminal portion of c-kit gene product carrier protein binding (K963)
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with c-Kit on Immunohistochemistry.
  • Research Area:
    Cell Biology
  • Short Description:
    CD117 Polyclonal Antibody.
  • Size:
    6 mL
  • Species Reactivity:
    Human
  • Storage Temperature:
    4°C
  • Target:
    CD117
Citations
  1. Berliocchi L et al. Autophagy impairment in a mouse model of neuropathic pain. Mol Pain. 7, 83 (2011),
  2. Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013),
  3. Matsunaga K et al. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol. 190, 511-21 (2010),
  4. Russo R et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis. 2, e144 (2011)
References
  1. Tsuura, T., et al., Virchows Archiv. 424, 135-141 (1994)
  2. Hidi, K., et al., Oncogene 6, 2291-2296 (1991)
  3. Yarden,Y., et al., EMBO J. 6, 3341-3351 (1987)