Anti-CD117 (c-Kit) (Human) pAb

  • Applications
    • IHC
    • WB
  • Target CD117
  • Host Species Rabbit
  • Species Reactivities Human
  • Code # 566
  • Size 100 µl
  • Price
    $373.17
Specifications

Background

c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
  • Antibody Type:
    Polyclonal
  • Application:
    IHC, WB
  • Conjugate:
    Unlabeled
  • Description:
    Polyclonal antibody of 100 µl targeting CD117 for WB, IHC.
  • Formulation:
    1 mg/mL in PBS/50% glycerol, pH 7.2
  • Gene ID (Human):
  • Host Species:
    Rabbit
  • Immunogen:
    Synthetic peptide C-terminal portion of c-kit gene product carrier protein binding (K963)
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Reactivity:
    This antibody reacts with c-Kit (145 kDa) on Western blotting and Immunohistochemistry.
  • Research Area:
    Cell Biology
  • Short Description:
    CD117 primary antibody.
  • Size:
    100 µl
  • Species Reactivity:
    Human
  • Storage Temperature:
    -20°C
  • Target:
    CD117
Citations
  1. Nonaka H, et al., Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Dev Dyn. 236:2258-67. 2007
References
  1. Tsuura, T., et al., Virchows Archiv. 424, 135-141 (1994)
  2. Hidi, K., et al., Oncogene 6, 2291-2296 (1991)
  3. Yarden,Y., et al., EMBO J. 6, 3341-3351 (1987)