Anti-Phospho-RB (Ser780) pAb: Trial Size

  • Applications
    • WB
  • Target RB
  • Host Species Rabbit
  • Species Reactivities Human, Mouse
  • Code # 555S
  • Size 10 µg
  • Price
    $110.84
Specifications

Background

Cyclin-dependent kinases (CDKs) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylation and attendant functional inactivation, the cell proceed into late G1. CyclinD-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclinE-Cdk2 and cyclinA-Cdk2 does not1.
  • Antibody Type:
    Polyclonal
  • Application:
    WB
  • Concentration:
    0.2 mg/mL
  • Conjugate:
    Unlabeled
  • Description:

    Polyclonal antibody of 10 µg targeting Phospho-RB for WB.

    For additional information, please see datasheet for standard vial.

  • Formulation:
    In PBS/1% BSA/10% glycerol/0.09% sodium azide
  • Gene ID (Human):
    5925
  • Gene ID (Mouse):
    19645
  • Host Species:
    Rabbit
  • Immunogen:
    Synthetic peptide (TRPPTLS (p) PIPHIP-KLH)
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Research Area:
    Cancer
  • Short Description:
    Phospho-RB Polyclonal Antibody.
  • Size:
    10 µg
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
    4°C
  • Target:
    RB
Citations
  1. Haruta M et al. TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen-presenting cells. Gene Ther. 20, 504-13 (2013),
  2. Panter MS et al. Dynamics of major histocompatibility complex class I association with the human peptide-loading complex. J Biol Chem. 287, 31172-84 (2012)