Anti-Phospho-RB (Ser780) pAb

  • Applications
    • WB
  • Target RB
  • Host Species Rabbit
  • Species Reactivities Human, Mouse
  • Code # 555
  • Size 100 µg
  • Price
    $306.33
Specifications

Background

Cyclin-dependent kinases (CDKs) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylation and attendant functional inactivation, the cell proceed into late G1. CyclinD-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclinE-Cdk2 and cyclinA-Cdk2 does not1.
  • Antibody Type:
    Polyclonal
  • Application:
    WB
  • Concentration:
    1 mg/mL
  • Conjugate:
    Unlabeled
  • Description:
  • Formulation:
    In PBS/50% glycerol, pH 7.2
  • Host Species:
    Rabbit
  • Immunogen:
    Synthetic peptide (TRPPTLS (p) PIPHIP-KLH)
  • Isotype:
    IgG
  • Product Type:
    Antibody
  • Research Area:
    Cancer
  • Short Description:
  • Size:
    100 µg
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
    -20°C
  • Target:
    RB
Citations
  1. Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)