Anti-Cyclin D1 (Human) pAb

  • Applications
    • FCM
    • ICC
    • IHC
    • IP
    • WB
  • Target Cyclin D1
  • Host Species Rabbit
  • Species Reactivities Human, Mouse
  • Code # 553
  • Size 100 µg
  • Price


Cyclin D1, also known as Bcl-1, CCND1, or PRAD-1, is a 36 kDa nuclear protein that plays a key regulatory role during the G1 phase of the cell cycle by regulating the activity of Cdk proteins. Cyclin D1 forms a complex with Cdk4, then binds to and phosphorylates Rb protein, triggering cells to progress from G0/G1 to S and thus driving cellular proliferation. Cyclin D1 protein overexpression is found in the majority of human breast cancers and is usually linked with poor prognosis. Overexpression of cyclin D1 is a well-established criterion for the diagnosis of Mantle Cell Lymphoma, and also has been used to distinguish malignant breast carcinomas from premalignant breast lesions.
  • Antibody Type:
  • Application:
  • Concentration:
    1 mg/mL
  • Conjugate:
  • Description:
  • Formulation:
    1.0 mg/mL in PBS/50% glycerol, pH 7.2
  • Host Species:
  • Immunogen:
    Terminal synthetic peptide of human Cyclin D1 C (EEEEEVDLACTPTDVRDVDI)
  • Isotype:
  • Product Type:
  • Reactivity:
    This antibody reacts with human and mouse cyclin D1 on Western blotting, Immunohistochemistry and Immunocytochemistry.
  • Research Area:
  • Short Description:
  • Size:
    100 µg
  • Species Reactivity:
    Human, Mouse
  • Storage Temperature:
  • Target:
    Cyclin D1
  1. Comitato A et al., Mutations in splicing factor PRPF3, causing retinal degeneration, form detrimental aggregates in photoreceptor cells. Hum Mol Genet. 16, 1699-707 (2007),
  2. Long SW et al., A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Biosci Rep. 31, 333-43 (2011),
  3. Maita H et al., Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex. Exp Cell Res. 302, 61-68 (2005)