Caspase inhibitor Z-VAD-FMK

  • Code # 4800-520
  • Size 20 μl (100mM)
  • Price
    $122.53
Specifications

Background

Caspases are members of the cysteine aspartic acid-specific protease family, which is activated by a variety of signals, including death receptor ligation, DNA damages, serum starvation and stress. Caspases play a role in chromatin fragmentation into nucleosome units, and caspase activation is associated with the unique apoptosis cell morphology of chromatin condensation, nucleus fragmentation and cytoplasmic integrity. Active caspase recognizes several molecules as substrates during apoptosis. For example, ICAD (inhibitor of caspase-activated deoxyribonuclease) is inactivated while CAD (caspase-activated deoxyribonuclease) is indirectly activated by caspase-3. Caspases recognize specific peptide sequences containing an aspartic acid, and cleave these substrate proteins immediately following this aspartic residue. The tri- peptide sequence “VAD” is broadly recognized by all group 1 caspases. Z-VAD-FMK is a powerful, irreversible and cell permeable inhibitor for caspases.
  • Description:
    Caspase inhibitor Z-VAD-FMK of 20 µl for study of apoptosis.
  • Formulation:
    100 mM Z-VAD-FMK in DMSO
  • Product Type:
    Reagent
  • Research Area:
    Apoptosis
  • Short Description:
    Caspase inhibitor Z-VAD-FMK
  • Size:
    20 μl (100mM)
  • Storage Temperature:
    -20°C
References
  1. Elizabeth A. S., et al. Biochem J., 315, 21-24 (1996)