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Tuesday, Oct 5th at 12:00PM ET; Presented by Dr. Orkash Hushur, MBL International
Wed, 16 Jun 2021 12:45:47 GMT
Thu, 18 Mar 2021 20:17:21 GMT
Isotype control antibodies are negative controls used to accurately measure antibody drug effects and efficacy for in vitro and in vivo monoclonal antibody (mAb) studies. Isotype controls match the test/primary antibody characteristics, but are raised against antigens not found in common preclinical species; this means that isotype controls lack specificity for the target antigen.
In both in vivo and in vitro assays, a signal can result from various binding events. In order to accurately interpret assay results, it is critical to differentiate between binding events such as:
mAb binding in an antigen-dependent specific manner.
mAb binding in a non-antigen dependent manner, due to interaction with Fc receptors (FcR) or other proteins.
Isotype control antibodies provide an ideal negative control for mAb efficacy studies, enabling researchers to accurately distinguish between non-specific background and specific antibody signal. Read more
Wed, 20 Jan 2021 18:00:00 GMT
MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines. Contact us today for more information.