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SARS-CoV-2

Analyze CD8+ T cell responses to SARS-CoV-2 with our new MHC Class I QuickSwitch™  tetramer kit and peptides bundles.

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MHC Tetramers

MHC Tetramers and Monomers for high specificity immune monitoring.

 

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Tetramer Staining Guide

MBL International’s new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.

Click below for more details and to receive a digital version.

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QuickSwitch™

HLA-A*02:01 Peptide Screening Kit

Quickly quantitate peptide-MHC binding affinity using high throughput screening assay.

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In Vivo Isotype Control Antibodies

CrownVivo™ in vivo isotype control antibodies are highly concentrated, low endotoxin, no preservatives, and available in bulk quantities.

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Customer Update – COVID-19

MBL International has been actively monitoring COVID-19 developments and want to assure you that the safety of our team and our customers is our primary focus. The COVID-19 pandemic presents a very fluid situation with challenges for each of us.

Learn more about how MBL International is responding to the safety of our employees and needs of our customers.

Download our most recent  Webinars!

Explore our video library of webinars as well as register for our upcoming webinars that focus on different life science research topics and applications.

  • Why should you use Isotype Control Antibodies

    Thu, 18 Mar 2021 20:17:21 GMTBy:

    Good experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
    What are Isotype Control Antibodies?

    Isotype control antibodies are negative controls used to accurately measure antibody drug effects and efficacy for in vitro and in vivo monoclonal antibody (mAb) studies. Isotype controls match the test/primary antibody characteristics, but are raised against antigens not found in common preclinical species; this means that isotype controls lack specificity for the target antigen.
    In both in vivo and in vitro assays, a signal can result from various binding events. In order to accurately interpret assay results, it is critical to differentiate between binding events such as:

    mAb binding in an antigen-dependent specific manner.
    mAb binding in a non-antigen dependent manner, due to interaction with Fc receptors (FcR) or other proteins.

    Isotype control antibodies provide an ideal negative control for mAb efficacy studies, enabling researchers to accurately distinguish between non-specific background and specific antibody signal. Read more

  • Human MHC Class II QuickSwitch™ Platform is used to Identify SARS-CoV-2 Virus Derived Peptides

    Wed, 20 Jan 2021 18:00:00 GMTBy:

    In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and making a determination on whether that fragment (also referred to as peptide) belongs in the body. Read more
  • How to Identify SARS-CoV-2 Virus Derived Peptides

    Thu, 19 Nov 2020 17:00:00 GMTBy:

    In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and making a determination on whether that fragment (also referred to as peptide) belongs in the body. We have also described in our previous blog post (Find Human MHC Class I Dominant Peptides) the multiple MHC alleles that we tested for their ability to present SARS-CoV-2 peptides. Read more

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MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.