Novel Neoantigen Screening Tool:  QuickSwitch™ Custom Tetramer Kits

A rapid high throughput and user friendly system for creating new tetramer specificities. Tetramers resulting from peptide exchange with selected peptides can be used for immune monitoring.

Useful for research involving cancer neoantigens, infectious agents and many other research areas.

Learn more about our QuickSwitch™ products.

• Replace your discontinued antibodies– with discount available for valid replacement.
• Share your review – write about your experience using an MBLI product and receive an award. Terms and Conditions apply.

COLLABORATE WITH MBLI

Partnering with pharmaceutical, biotechnology, and diagnostics companies to out-license our innovative technologies and products supporting life science research, develop companion diagnostics and in-license IVD technologies/products in the areas of cancer, autoimmune diseases, infectious diseases, allergy and cytological/pathological testing.

MBL International will be attending:

• June 18 – 21 World Preclinical Congress in Boston
• July 29 – Aug 2 AACC 2018 in Chicago
• November 7 – 11 SITC 2018 in Washington, DC

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Press Release

JSR’s Life Sciences Division Appoints New CEO for MBL International

Jan. 23, 2018 – Sunnyvale, CA – JSR Life Sciences, the life sciences-focused business unit of JSR Corporation, announced today that it has appointed Dr. Nalini Murdter as the President and Chief Executive Officer of MBL International (MBLI) effective immediately.

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May 22nd, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. (MBL) announced that it has entered into a collaboration agreement with the p53 Laboratory, Agency for Science, Technology and Research (A*STAR) in Singapore to establish the novel screening technology which accelerates the drug discovery targeting Protein-Protein Interactions (PPIs).

February 28th, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. concludes a patent licensing agreement with the University of Toyama concerning a rapid antibody production technique

• Fluoppi Protein-Protein Interaction – Visualize and Screen PPI’s with 18 new pre-made vector sets of popular oncology targets
• Next-Generation Nano Culture Plates – 3D Cell Culture plates for tumor modeling and other applications, easy to use with improved imaging
• ELISA Kits and Antibodies -13 New Targets, including high quality Oryza sativa Transport inhibitor response 1 antibody
• TransFix® – A patented stabilization solution that is easy to use and preserves cells and cellular antigens for up to 14 days prior to analysis

• Improve your neutralization using monoclonal IL-18 antibodies

  Tue, 19 Jun 2018 17:00:00 GMTBy: nakajo.tomohiro@mbl.co.jp (Tomohiro Nakajo)

  Interleukin-18 (IL-18) is a member of the IL-1 superfamily and synthesized as an inactive precursor that requires processing by caspase-1 to become an active cytokine. IL-18 plays a major role in the production of interferon-γ (IFN-γ) from T cells and natural killer cells. Refresh your memory by reviewing a couple of previous blog posts. Read more

• Tips for successful results using our extremely popular IL-18 ELISA kits

  Wed, 30 May 2018 17:00:00 GMTBy: nakajo.tomohiro@mbl.co.jp (Tomohiro Nakajo)

  Interleukin-18 (IL-18) is a member of the IL-1 superfamily and synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine. IL-18 plays a major role in the production of interferon-γ (IFNγ) from T cells and natural killer cells. Refresh your memory by reviewing a couple of previous blog posts.
  MBL is the first supplier of antibodies and ELISA kits for IL-18. These reagents have become the gold standard worldwide in IL-18 research area. You may have heard about clone #125-2H or ELISA kit code #7620 since they are developed and manufactured by MBL.
  Our ELISA kit for human IL-18 (code #7620) and mouse IL-18 (code #7625) are the most cited kits for IL-18. Therefore, we have been able to accumulate significant information from researchers. For example, researchers have shown our ELISA kits can be used to detect IL-18 levels in various samples that we have not tested. Our ELISA kits have been tested using serum, plasma, and cell culture supernatant by MBL. However, as publications are released, we have learned that it also can be used for urine, tissue homogenate, etc.  If you want to use other samples to measure IL-18, please contact us. We can lead you to the correct citation to help you.

  Human urine samples

  Am Soc Nephrol. 2010 Jan; 21(1):189-97. (PMID: 19762491)
  Nephrol Dial Transplant. 2008 Feb; 23(2):566-72. (PMID:17911094)
  J Am Soc Nephrol. 2005 Oct; 16(10):3046-52. (PMID:16148039)

  Mouse tissue homogenate

  J Biol Chem. 2012 Nov 23; 287(48):40391-9. (PMID: 23027874)
  J Biol Chem. 2012 May 11; 287(20):16955-64. (PMID: 22461621)
  Int Immunol. 2010 Jul; 22(7):561-70. (PMID: 20497957)

  Another frequent inquiry pertains to “cross reactivity to pro-IL-18”.  We have answers for this question! We measured the OD values of recombinant pro-IL-18 when we constructed ELISAs. As a result, human pro-IL-18 OD was around 0.7% OD of human mature IL-18 standard. In mouse, it was less than 10%. Therefore, we can answer that the cross-reactivity of #7620 with pro-IL-18 is around 0.7%, and #7625 is less than 10%.
  Please do not hesitate to contact us if you have any questions. We are happy to help you based on knowledge we have obtained by offering gold standards for detecting IL-18. Read more

• How do I even get started? Lessons for setting up your experiments

  Thu, 26 Apr 2018 17:00:00 GMTBy: bindi.doshi@mblintl.com (Bindi M. Doshi, PhD)

  Biology can be daunting.  Experiments can be daunting.  Setting up your own biological experiments can be terrifying!  But it doesn’t need to be. 
  The first steps are to learn, research, and read.  Read as much as you can about the area where you have written up your hypothesis.  What has already been done?  What questions do you come up with to further strengthen the field and make a nice story for your project?  What experiments did other researchers do?  Learn what cell lines they used, and how they designed controls. 
  Once you feel that you have a good understanding of the background and what questions you want to explore, you can then start designing your experiment!  Look to see what materials you already have in your lab and determine which ones you may need to order.  Keep in mind, if you need to make a purchase, some materials may have a long lead time for delivery. 
  You may also want to get in touch with other researchers and see if they have any advice for you.  The more experiments you try, the more mistakes you might make, but the more you will learn.  And before you know it, you will have mastered various techniques and other researchers will come to you for advice! Read more

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