Come visit us at AAI23 in Washington DC-We have a Poster Presentation and an exciting Workshop!

Product kit box change announcement: We will use the new kit box for several products. There is no change in the product components. Click here for detailed information.

We are Exhibiting at AACR23-Come visit us at booth #2864 and check out our poster!

Press Release: Woburn, MA – July 28, 2021, MBL International Launches QuickSwitch™ Class II Custom MHC Tetramer Kits

Product Data Sheets Not Included With Shipment:

Currently, MBLI products are delivered with the product data sheet included in the package. This is an announcement that we will stop including the product data sheet in the package for certain products. It will be applied sequentially to batches manufactured after April 2022 for some products. You can download the product data sheet from our website whenever you need. Allow us to apologize for any inconvenience this may have caused you.

Label Change Announcement:

Many of our products currently utilize clear-color vial tube labels. We will be changing the color of the labels to white for production lots manufactured after February 1, 2022. The product description written on the label and product itself will not be changed.

Customer Update – COVID-19

MBL International has been actively monitoring COVID-19 developments and want to assure you that the safety of our team and our customers is our primary focus. The COVID-19 pandemic presents a very fluid situation with challenges for each of us.

Learn more about how MBL International is responding to the safety of our employees and needs of our customers.

Download our on demand webinars!

Explore our video library of webinars focused on different life science research topics and applications.  All webinars are presented by our scientists at MBL International.

• Innate Immunity ELISA Kits – 9 new ELISA kits for immune response detection.
• QuickSwitch™ Class II Human Tetramer Kit – Novel kit for creating your own custom human Class II MHC tetramers
• In Vivo Isotype Control Antibodies – Highly concentrated, low endotoxin, low preservatives, available in bulk quantities.
• QuickSwitch™ Peptide Screening Kit – Quickly quantitate peptide-MHC binding affinity
• QuickSwitch™ HLA-A*03:01 Tetramer Kits – Quickly generate new high-quality tetramer specificities
• SARS-CoV2 Tetramers – Targeted T-cell detection for SARS-CoV2 immune detection
• QuickSwitch™ HLA-A*11:01 Tetramer Kits – Generate new high-quality tetramer specificities quickly!
• T-Select Human MR1 Tetramer – Use to recognize human MAIT cells binding to MR1/MR1-ligand complex

• IL-18 Therapies Targeting Inflammatory Disease

  Thu, 25 May 2023 16:43:35 GMTBy: beata@mblintl.com (Beata Boczkowska, Ph.D.)

  Interleukin-18 (IL-18) is an effective pro-inflammatory cytokine for the host defense against infections and controls the innate and acquired immune response. Both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes, and mesenchymal cells produce IL-18. IL-18 can increase Th1 responses and is critical for IFN-gamma production. IL-18 is regulated by IL-18BP by inhibiting the biological activity of IL-18, thereby reducing IFN-gamma production in turn suppressing the Th1 immune responses. The dysregulation of the IL-18/IL-18BP balance is associated with multiple biological effects and pathological outcomes (1). Both IL-18 and IL18BP are connected to developing psoriasis, atopic dermatitis (AD), lupus erythematosus (LE), and other inflammatory skin diseases. Still, IL-18 is more prominently involved with chronic inflammation and autoimmune disease such as inflammatory bowel diseases, type I diabetes mellitus, chronic liver disease, adult-onset Still’s disease, hemophagocytic syndrome, rheumatoid arthritis, and idiopathic thrombocytopenic purpura. Read more

• Recent Peptide-MHC Exchange Publications Using QuickSwitch™ Technology

  Thu, 30 Mar 2023 12:57:42 GMTBy: bindi.doshi@mblintl.com (Bindi M. Doshi, PhD)

  MHC-peptide exchange is considered to be tricky by researchers.  However, with the right set of tools and protocols, this peptide-MHC exchange can be done easily, quickly, and provide robust information.  Recent publications highlight how various researchers have used QuickSwitch™ kits for their applications. Read more

• Crucial Niche Factors for Organoid Cultures

  Fri, 17 Mar 2023 20:34:51 GMTBy: bindi.doshi@mblintl.com (Bindi M. Doshi, PhD)

  Organoids are 3D structures made up of cells that replicate the structure and function of tissues and organs. Organoids can be derived from stem cells or tissue-specific progenitor cells. A stem cell niche is the specific microenvironment that regulates the stem cell behaviors. Many researchers try to recreate these stem cell niches in vitro. However, it is difficult to create the appropriate cell culture conditions for stem cell growth. Here we discuss current advances made to help create and maintain organoid cultures. Read more

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MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.