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MBL International provides high-quality products and solutions to advance life science research and clinical diagnostics.

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Product Highlight

MHC Tetramers

 

MHC Tetramers and Monomers for high specificity immune monitoring.

Patented α3 mutation for reduced background.

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Product Highlight

TransFix®: A Cellular Antigen Stabilization Reagent

 

TransFix® is a versatile cellular antigen stabilization solution that prevents cellular degradation in a variety of specimen types for flow cytometric analysis.

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Product Highlight

Immuno-Oncology Solutions

MBL International offers Antibodies, MHC Tetramers and Monomers to study immune checkpoint and other cancer research targets.

 

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Product Highlight

IL-18 (Interleukin 18)

MBL International’s IL-18 products are highly cited and widely trusted.

We offer a wide range of Antibodies, ELISA Kits and Recombinant Proteins.

Discover how MBL International can help your IL-18 research.

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TransFix/EDTA Vacuum Blood Collection Tubes (TVTs)

TVTs are now available in a convenient 2-tube pack presentation for in vitro diagnostic (IVD) use in the USA.

TransFix/EDTA Vacuum Blood Collection Tubes (TVTs) are intended for collection and storage of human whole blood specimens for immunophenotyping of white blood cells by flow cytometry.

Now, IVD TransFix/EDTA Vacuum Blood Collection Tubes are available in a convenient 2-tube pack presentation, as well as 50-tube packs.

Learn More about this TransFix product.

 

 

 

COLLABORATE WITH MBLI

Partnering with pharmaceutical, biotechnology, and diagnostics companies to out-license our innovative technologies and products supporting life science research, develop companion diagnostics and in-license IVD technologies/products in the areas of cancer, autoimmune diseases, infectious diseases, allergy and cytological/pathological testing.

MBL International will be attending:

  • November 7 – 11 SITC 2018 in Washington, DC

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Press Release

JSR’s Life Sciences Division Appoints New CEO for MBL International

 

Jan. 23, 2018 – Sunnyvale, CA – JSR Life Sciences, the life sciences-focused business unit of JSR Corporation, announced today that it has appointed Dr. Nalini Murdter as the President and Chief Executive Officer of MBL International (MBLI) effective immediately.

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May 22nd, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. (MBL) announced that it has entered into a collaboration agreement with the p53 Laboratory, Agency for Science, Technology and Research (A*STAR) in Singapore to establish the novel screening technology which accelerates the drug discovery targeting Protein-Protein Interactions (PPIs).

February 28th, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. concludes a patent licensing agreement with the University of Toyama concerning a rapid antibody production technique

 

 

  • Fc blockers to reduce background in Tetramer staining

    Tue, 25 Sep 2018 17:00:00 GMTBy: nakajo.tomohiro@mbl.co.jp (Tomohiro Nakajo)

    Fc blockers are needed for monocytes, macrophages, B cells and granulocytes. Since T cells normally do not express Fc receptors, some investigators do not use Fc blockers and instead use a dump channel (e.g. CD14/CD19) during flow cytometry analysis to exclude Fc-expressing populations.  Read more
  • Which tetramers can be used for my mouse samples?

    Tue, 28 Aug 2018 17:00:00 GMTBy: nakajo.tomohiro@mbl.co.jp (Tomohiro Nakajo)

    The thymus shapes a host’s T-cell repertoire so they do not respond to “self” antigens, yet are able to recognize “non-self” antigen challenges (from pathogens and tumors). T cell participation in these immune responses are dependent on interaction with peptide- and self-MHC. In other words, T cells only recognize the peptides derived from cancers or pathogens if they are embedded in the cleft of self host MHC grooves. Such peptides are processed and presented on the surface of antigen-presenting cells (MHC class I and II in dendritic cells, macrophages, and B cells) or all nucleated cells (MHC class I) allowing T cells to identify infected or cancer cells. Direct detection of such Ag-specific T cells and functional analysis is important for understanding disease immunopathogenesis and the process of drug development. MBL International has had tremendous success in advancing the methodologies to accurately measure antigen-specific T cells.  Read more
  • Learn why IL-18 is an exciting biomarker for various diseases

    Tue, 31 Jul 2018 17:00:00 GMTBy: nakajo.tomohiro@mbl.co.jp (Tomohiro Nakajo)

    As described in previous blog posts, our IL-18 related products are used widely among researchers around the world. IL-18 plays an important role in the cytokine network. Abnormal values of IL-18 are seen in various disease areas such as allergy or autoimmune diseases. 
    In this blog, we discuss two diseases correlated with IL-18. Neither of them are allergy or autoimmune diseases, but very interesting nonetheless. Read more

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