Customer Update – COVID-19

MBL International has been actively monitoring COVID-19 developments and want to assure you that the safety of our team and our customers is our primary focus. The COVID-19 pandemic presents a very fluid situation with challenges for each of us.

Learn more about how MBL International is responding to the safety of our employees and needs of our customers.

Register for our upcoming webinar!

Join Dr. Yuri Poluektov for our upcoming webinar “Simulating COVID-19 peptide presentation using the QuickSwitch™ MHC Platform”.

Webinar Date and Time:  Tuesday, July 13th at 12:00PM ET.

• In Vivo Isotype Control Antibodies – Highly concentrated, low endotoxin, low preservatives, available in bulk quantities.
• QuickSwitch™ Peptide Screening Kit – Quickly quantitate peptide-MHC binding affinity
• QuickSwitch™ HLA-A*03:01 Tetramer Kits – Quickly generate new high-quality tetramer specificities
• SARS-CoV2 Tetramers – Targeted T-cell detection for SARS-CoV2 immune detection
• Magnosphere™ Magnetic Beads – Magnetic beads for life sciences research
• Immutex™ Latex Beads– Variety of particle sizes and surface chemistries are available
• QuickSwitch™ HLA-A*11:01 Tetramer Kits – Generate new high-quality tetramer specificities quickly!
• T-Select Human MR1 Tetramer – Use to recognize human MAIT cells binding to MR1/MR1-ligand complex

• Why should you use Isotype Control Antibodies

  Thu, 18 Mar 2021 20:17:21 GMTBy:

  Good experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
  What are Isotype Control Antibodies?

  Isotype control antibodies are negative controls used to accurately measure antibody drug effects and efficacy for in vitro and in vivo monoclonal antibody (mAb) studies. Isotype controls match the test/primary antibody characteristics, but are raised against antigens not found in common preclinical species; this means that isotype controls lack specificity for the target antigen.
  In both in vivo and in vitro assays, a signal can result from various binding events. In order to accurately interpret assay results, it is critical to differentiate between binding events such as:

  mAb binding in an antigen-dependent specific manner.
  mAb binding in a non-antigen dependent manner, due to interaction with Fc receptors (FcR) or other proteins.

  Isotype control antibodies provide an ideal negative control for mAb efficacy studies, enabling researchers to accurately distinguish between non-specific background and specific antibody signal. Read more

• Human MHC Class II QuickSwitch™ Platform is used to Identify SARS-CoV-2 Virus Derived Peptides

  Wed, 20 Jan 2021 18:00:00 GMTBy:

  In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and making a determination on whether that fragment (also referred to as peptide) belongs in the body. Read more

• How to Identify SARS-CoV-2 Virus Derived Peptides

  Thu, 19 Nov 2020 17:00:00 GMTBy:

  In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and making a determination on whether that fragment (also referred to as peptide) belongs in the body. We have also described in our previous blog post (Find Human MHC Class I Dominant Peptides) the multiple MHC alleles that we tested for their ability to present SARS-CoV-2 peptides. Read more

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MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.