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Analyze CD8+ T cell responses to SARS-CoV-2 with our new MHC Class I QuickSwitch™  tetramer kit and peptides bundles.

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MHC Tetramers

MHC Tetramers and Monomers for high specificity immune monitoring.


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Tetramer Staining Guide

MBL International’s new Tetramer Staining Guide is a collection of protocols and data to help make your experiments a success.

Click below for more details and to receive a digital version.

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Class II Human Tetramer Kits

Novel kit for creating your own custom human Class II MHC Tetramers.

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In Vivo Isotype Control Antibodies

CrownVivo™ in vivo isotype control antibodies are highly concentrated, low endotoxin, no preservatives, and available in bulk quantities.

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Come visit us at AAI23 in Washington DC-We have a Poster Presentation and an exciting Workshop!

Product kit box change announcement: We will use the new kit box for several products. There is no change in the product components. Click here for detailed information.

We are Exhibiting at AACR23-Come visit us at booth #2864 and check out our poster!

Press Release: Woburn, MA – July 28, 2021, MBL International Launches QuickSwitch™ Class II Custom MHC Tetramer Kits

Product Data Sheets Not Included With Shipment:

Currently, MBLI products are delivered with the product data sheet included in the package. This is an announcement that we will stop including the product data sheet in the package for certain products. It will be applied sequentially to batches manufactured after April 2022 for some products. You can download the product data sheet from our website whenever you need. Allow us to apologize for any inconvenience this may have caused you.

Label Change Announcement:

Many of our products currently utilize clear-color vial tube labels. We will be changing the color of the labels to white for production lots manufactured after February 1, 2022. The product description written on the label and product itself will not be changed.

Customer Update – COVID-19

MBL International has been actively monitoring COVID-19 developments and want to assure you that the safety of our team and our customers is our primary focus. The COVID-19 pandemic presents a very fluid situation with challenges for each of us.

Learn more about how MBL International is responding to the safety of our employees and needs of our customers.

Download our on demand webinars!

Explore our video library of webinars focused on different life science research topics and applications.  All webinars are presented by our scientists at MBL International.

  • Integrin αvβ6: An indicator of inflammation and ulcerative colitis

    Thu, 07 Sep 2023 19:22:08 GMTBy: (Beata Boczkowska, Ph.D.)

    Integrins are heterodimeric cell surface receptors involved in cell-extracellular matrix and cell-cell adhesion. In addition, integrins convey two-way signaling between cells and their surroundings and participate in the regulation of a variety of cellular processes, including cell proliferation, migration,survival, tissue invasion, and innate immunity. Mammalian cells have 18 distinct integrin α subunits and 8 β subunits, which can combine in various ways to form 24 different receptor heterodimers. Integrin αvβ6 is expressed exclusively by epithelial cells and functions as a receptor for extracellular matrix proteins such as fibronectin.  Read more

  • Correlation Between HLA Typing and Immune Monitoring in Human Disease

    Thu, 13 Jul 2023 16:05:43 GMTBy: (Beata Boczkowska, Ph.D.)

    The HLA (human leukocyte antigen) system, also known as the human MHC (major histocompatibility complex), was named after its discovery with alloantibodies against leukocytes. The human MHC is located on the short arm of chromosome 6 (6p21) and spans 3,600 kilobases of DNA. It is divided into three regions, with HLA being one of the most diverse genetic systems in humans (1). Read more

  • IL-18 Therapies Targeting Inflammatory Disease

    Thu, 25 May 2023 16:43:35 GMTBy: (Beata Boczkowska, Ph.D.)

    Interleukin-18 (IL-18) is an effective pro-inflammatory cytokine for the host defense against infections and controls the innate and acquired immune response. Both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes, and mesenchymal cells produce IL-18. IL-18 can increase Th1 responses and is critical for IFN-gamma production. IL-18 is regulated by IL-18BP by inhibiting the biological activity of IL-18, thereby reducing IFN-gamma production in turn suppressing the Th1 immune responses. The dysregulation of the IL-18/IL-18BP balance is associated with multiple biological effects and pathological outcomes (1). Both IL-18 and IL18BP are connected to developing psoriasis, atopic dermatitis (AD), lupus erythematosus (LE), and other inflammatory skin diseases. Still, IL-18 is more prominently involved with chronic inflammation and autoimmune disease such as inflammatory bowel diseases, type I diabetes mellitus, chronic liver disease, adult-onset Still’s disease, hemophagocytic syndrome, rheumatoid arthritis, and idiopathic thrombocytopenic purpura. Read more

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MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.