Press Release: Woburn, MA – July 28, 2021, MBL International Launches QuickSwitch™ Class II Custom MHC Tetramer Kits

Customer Update – COVID-19

MBL International has been actively monitoring COVID-19 developments and want to assure you that the safety of our team and our customers is our primary focus. The COVID-19 pandemic presents a very fluid situation with challenges for each of us.

Learn more about how MBL International is responding to the safety of our employees and needs of our customers.

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• QuickSwitch™ Class II Human Tetramer Kit – Novel kit for creating your own custom human Class II MHC tetramers
• In Vivo Isotype Control Antibodies – Highly concentrated, low endotoxin, low preservatives, available in bulk quantities.
• QuickSwitch™ Peptide Screening Kit – Quickly quantitate peptide-MHC binding affinity
• QuickSwitch™ HLA-A*03:01 Tetramer Kits – Quickly generate new high-quality tetramer specificities
• SARS-CoV2 Tetramers – Targeted T-cell detection for SARS-CoV2 immune detection
• QuickSwitch™ HLA-A*11:01 Tetramer Kits – Generate new high-quality tetramer specificities quickly!
• T-Select Human MR1 Tetramer – Use to recognize human MAIT cells binding to MR1/MR1-ligand complex

• Stop Crying in the Lab: How Cry Antibodies Can Help Your Research

  Wed, 16 Jun 2021 12:45:47 GMTBy: deane.buckley@mblintl.com (Deane Buckley)

   
  Figure: Schematic representation of feedback loop involving CLOCK-BMAL1 complex and CRY and PER proteins involved in creating circadian rhythms.
  Tiredness and frustration often mount after long nights in the lab. Why can’t our bodies adjust and allow us to maintain our energy through the night? The answer lies in our circadian rhythms. Circadian rhythms are the daily cycle of biological processes such as wakefulness and metabolism1. Many proteins are involved in regulating our circadian rhythms including CRY proteins. This blog post will catch you up on these proteins and their vital role in regulating circadian rhythms. Read more

• Why should you use Isotype Control Antibodies

  Thu, 18 Mar 2021 20:17:21 GMTBy:

  Good experimental design is key to accurate and precise drug development. Isotype control antibodies, designed and deployed properly, optimize study performance and data analysis in therapeutic antibody research.
  What are Isotype Control Antibodies?

  Isotype control antibodies are negative controls used to accurately measure antibody drug effects and efficacy for in vitro and in vivo monoclonal antibody (mAb) studies. Isotype controls match the test/primary antibody characteristics, but are raised against antigens not found in common preclinical species; this means that isotype controls lack specificity for the target antigen.
  In both in vivo and in vitro assays, a signal can result from various binding events. In order to accurately interpret assay results, it is critical to differentiate between binding events such as:

  mAb binding in an antigen-dependent specific manner.
  mAb binding in a non-antigen dependent manner, due to interaction with Fc receptors (FcR) or other proteins.

  Isotype control antibodies provide an ideal negative control for mAb efficacy studies, enabling researchers to accurately distinguish between non-specific background and specific antibody signal. Read more

• Human MHC Class II QuickSwitch™ Platform is used to Identify SARS-CoV-2 Virus Derived Peptides

  Wed, 20 Jan 2021 18:00:00 GMTBy:

  In our previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) we have described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and making a determination on whether that fragment (also referred to as peptide) belongs in the body. Read more

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MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.