Novel Neoantigen Screening Tool:  QuickSwitch™ Custom Tetramer Kits

A rapid high throughput and user friendly system for creating new tetramer specificities. Tetramers resulting from peptide exchange with selected peptides can be used for immune monitoring.

Useful for research involving cancer neoantigens, infectious agents and many other research areas.

Learn more about our QuickSwitch™ products.

• Mega discounts on select Nanoculture products – up to 30% off.
• Claim your free 2 pack TransFix – with the purchase of our ExoCap kit.

• Replace your discontinued antibodies– with discount available for valid replacement.
• Share your review – write about your experience using an MBLI product and receive an award. Terms and Conditions apply.

MBL International is here to work with you and advance your unique research needs using custom services. We can help with Immuno-monitoring services using MHC Tetramers and Cytokines.  Contact us today for more information.

MBL International will be exhibiting at the following shows:

March 29 – April 3: AACR 2019 in Atlanta, GA

May 9 – May 13: Immunology 2019 in San Diego, CA

Press Release

JSR’s Life Sciences Division Appoints New CEO for MBL International

Jan. 23, 2018 – Sunnyvale, CA – JSR Life Sciences, the life sciences-focused business unit of JSR Corporation, announced today that it has appointed Dr. Nalini Murdter as the President and Chief Executive Officer of MBL International (MBLI) effective immediately.

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May 22nd, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. (MBL) announced that it has entered into a collaboration agreement with the p53 Laboratory, Agency for Science, Technology and Research (A*STAR) in Singapore to establish the novel screening technology which accelerates the drug discovery targeting Protein-Protein Interactions (PPIs).

February 28th, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. concludes a patent licensing agreement with the University of Toyama concerning a rapid antibody production technique

• Afamin/Wnt3a Culture Medium – New serum free culture medium that allows for long term organoids to be made possible.
• T-Select Human MR1 Tetramer – Use to recognize human MAIT cells binding to MR1/MR1-ligand complex
• Fluoppi Protein-Protein Interaction – Visualize and Screen PPI’s with 18 new pre-made vector sets of popular oncology targets
• TransFix® – A patented stabilization solution that is easy to use and preserves cells and cellular antigens for up to 14 days prior to analysis

• 3D cell imaging made easier

  Tue, 29 Jan 2019 18:00:00 GMTBy: bindi.doshi@mblintl.com (Bindi M. Doshi, PhD)

  There is an increase in demand for scientists to show cell migration and proliferation on a surface that more closely mimics an in vivo environment.  Using a gel surface can be tricky.  Therefore, MBL has a unique and innovative technology where a proprietary plastic film is used for plating cells.  This technology is easy to use with many different cell types and is reproducible every time.  Please see the table below comparing various techniques for 3D cell cultures: Read more

• LC3: The gold standard for autophagy research

  Thu, 13 Dec 2018 18:00:00 GMTBy:

  LC3, a mammalian homologue of yeast ATG8, is a soluble protein that is distributed ubiquitously in mammalian tissues and cultured cells. LC3 has been studied most extensively and is frequently used as an autophagy marker in mammals.  Newly translated LC3 (proLC3) is immediately processed at the C-terminus in order to form LC3-I. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles. Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes. Read more

• Gating strategy for tetramer analysis to eliminate non-specific event

  Wed, 14 Nov 2018 18:00:00 GMTBy:

  While MHC tetramer staining of antigen specific T cells for flow cytometry is considered highly specific, it could still be associated with non-specific staining. The gating strategy shown below is an example that investigators have used to reduce non-specific staining events using a dump channel. A dump channel can be planned on a case by case basis, on the experimental design, and consists of a pool of antibodies against cells that do not express our specific targets. For example, CD8+ T cells, anti-CD4/anti-CD14/anti-CD19 may be used to eliminate these immune cells from our targeted gate, and all may be labeled with the same fluorochrome.  Read more

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