MBL International provides high-quality products and solutions to advance life science research and clinical diagnostics.

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Product Highlight

MHC Tetramers


MHC Tetramers and Monomers for high specificity immune monitoring.

Patented α3 mutation for reduced background.

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Product Highlight

TransFix®: A Cellular Antigen Stabilization Reagent


TransFix® is a versatile cellular antigen stabilization solution that prevents cellular degradation in a variety of specimen types for flow cytometric analysis.

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Immuno-Oncology Solutions

MBL International offers Antibodies, MHC Tetramers and Monomers to study immune checkpoint and other cancer research targets.


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Autoimmune ANA Test Systems

We offer screens for a wide range of autoantibodies with each lot tested to ensure lot to lot sensitivity.

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TransFix/EDTA Vacuum Blood Collection Tubes (TVTs)

TransFix Vacuum Tubes are now available for in vitro diagnostic (IVD) use in the USA, for immunophenotyping of white blood cells by flow cytometry.

By stabilizing samples with TransFix/EDTA Vacuum Blood Collection Tubes, recovery of lymphocyte subset markers for the HIV panel can be accomplished over a 14-day period following collection. This is particularly important in the routine diagnosis and immune monitoring of HIV patients.

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Partnering with pharmaceutical, biotechnology, and diagnostics companies to out-license our innovative technologies and products supporting life science research, develop companion diagnostics and in-license IVD technologies/products in the areas of cancer, autoimmune diseases, infectious diseases, allergy and cytological/pathological testing.

  • Antibodies for fluorescent proteins: Will it cross react with my variant?

    Tue, 27 Feb 2018 18:00:00 GMTBy: (Tomohiro Nakajo)

    Green fluorescent protein (GFP) was first isolated by Dr. Osamu Shimomura in 1961. Since then, fluorescent protein (FP) technology has made drastic advancements by many researchers. Currently, FP technology is the most popular tool for visualizing target proteins. Dr. Shimomura, Martin Chalfie and Roger Y. Tsien won the 2008 Nobel Prize in Chemistry to mark their great achievements in life science research. Read more
  • S100 Proteins: Study their Hundreds of Functions with MBL ELISA Kits

    Wed, 24 Jan 2018 18:00:00 GMTBy: (Tomohiro Nakajo)

    Have you heard of the S100 protein family? S100 refers to proteins that are 100% soluble in saturated ammonium sulfate solution. They were first discovered as a major protein fraction (0.6% of total soluble proteins) isolated from bovine brain by B.W. Moore in 1965.
    The S100 protein family consists of calcium binding proteins with 2 distinct helix-loop-helix motifs (EF-hands), existing as a homodimer. Currently 20 family members are known and have been found to be secreted extracellularly as well as to be involved in intracellular signaling. Many of the functions of the S100 protein family are currently unknown. Recent research has suggested an association with various diseases such as cancer, inflammation, and atherosclerosis. For example, levels of S100A4, A6, A14, and P are upregulated in many cancers. S100A7 has been studied in skin inflammatory disease and S100A12 and Calprotectin (only one heterodimer consisting of S100A8 and A9) have been studied in inflammatory bowel disease. 
    MBLI offers 12 sandwich ELISA kits for this protein family. If you want to know detailed information of each isoform of S100, please visit our website. 
    MBLI S100 ELISA kits are highly cited, particularly our S100A12 kit. Below is a partial list of citations with sample type and disease correlations. These kits have been used for the analysis of many diseases using various samples, not only serum/plasma but also cerebrospinal fluid (CSF), bronchoalveloar lavage fluid (BALF), and more. A citation highlight includes the measurement of S100A12 (CY-8058V2) in a stool sample. MBLI’s S100A7 ELISA kit (CY-8073) can be used with the sample of washing fluid from skin. This sample preparation method is written in its datasheet.  Read more
  • Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.

    Tue, 09 Jan 2018 15:24:11 GMTBy: (Tomohiro Nakajo)

    Mechanisms of Autophagy
    The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly to the autophagosome marker LC3 and is then selectively degraded by autophagy.
    p62 contains multiple phosphorylation sites. Sequential phosphorylation of these sites regulates biological defense mechanisms such as selective autophagy and the Keap1-Nrf2 system. Therefore, the failure of the p62 pathway is associated with various diseases such as cancer and many neurodegenerative diseases.
    To learn more about the mechanisms of p62, please refer to our whitepaper written by Drs. Masaaki Komatsu and Yoshinobu Ichimura, Niigata University. They are leading researchers in Autophagy,  especially p62 and Keap1-Nrf2 interaction. Dr. Komatsu was recognized as one of the most highly cited researchers in Autophagy in 2014 and 2015 by Clarivate Analytics.

    p62 Detection
    How do you detect p62 or phospho-p62 using antibodies? Western blotting? Immunohistochemistry?  Quantification of biomarkers is essential for medical and diagnostic application. Selective autophagy and Keap1-Nrf2 are already being discussed for their use as a diagnostic as well as other medical applications.
    MBL International has developed new sandwich ELISA kits that can semi-quantify total p62 and its phosphorylation level at Ser403 and Ser349. Phospho-p62 ELISA kits are the first kits to quantify these markers by ELISA in the world research market. It is a chance to get a new discovery in the Autophagy area!

    CY-7055: CycLex® Total p62 ELISA Kit

    CY-7057: CycLex® Phospho-p62 Ser403 ELISA Kit

    CY-7056:  CycLex® Phospho-p62 Ser349 ELISA Kit

    These kits can help you to prepare cell lysate easily including cell lysis buffers. Phosphatase inhibitor solution is also included in the phosho-p62 kits. They can be used for human and mouse samples.
    Total p62 and phospho-p62 levels in HeLa cells Read more

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Press Release

JSR’s Life Sciences Division Appoints New CEO for MBL International


Jan. 23, 2018 – Sunnyvale, CA – JSR Life Sciences, the life sciences-focused business unit of JSR Corporation, announced today that it has appointed Dr. Nalini Murdter as the President and Chief Executive Officer of MBL International (MBLI) effective immediately.

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May 22nd, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. (MBL) announced that it has entered into a collaboration agreement with the p53 Laboratory, Agency for Science, Technology and Research (A*STAR) in Singapore to establish the novel screening technology which accelerates the drug discovery targeting Protein-Protein Interactions (PPIs).

February 28th, 2017: MEDICAL & BIOLOGICAL LABORATORIES Co., Ltd. concludes a patent licensing agreement with the University of Toyama concerning a rapid antibody production technique



  • p62 ELISA Kits– Complementary products to our p62 antibodies and extensive autophagy antibody portfolio
  • QuickSwitch™ Custom Tetramer Kits – Create new specificity tetramers for antigen-specific t cell detection in just a few hours
  • TransFix® – A patented stabilization solution that is easy to use and preserves cells and cellular antigens for up to 14 days prior to analysis
  • Exosome Storage Booster – Improve the recovery rate of exosomes from cell culture supernatant using ultracentrifugation