anti-EIF2C2/AGO2

Datasheet:

Background:

Eukaryotic translation initiation factor 2C, subunit 2 (EIF2C2; AGO2), is a member of the argonaute protein family. It is a core component of RNA-induced silencing complex (RISC). The EIF2C2 belonging to the human argonaute protein family possesses endonuclease activity and functions as a slicer in gene silencing pathways. It recognizes and cleaves target mRNA by RNA interference. In small interference RNA (siRNA) pathway, EIF2C2 forms a complex with EIF2C1 and siRNA, and in microRNA (miRNA) pathway, it binds EIF2C3 to miRNA. EIF2C2 expression is controlled by epidermal growth factor receptor and mitogen-activated protein kinase signaling in human breast cancer cell line.

Size:

100 μL

Application:

IPP

Application:

WB

Product Type:

Primary Antibody

Host Species:

Mouse

Isotype:

IgG2a lambda

Storage Temp. (°C):

4

Shipping Temp. (°C):

-20

Pictures:

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References:

Adams, B. D., et al., Endocrinology 150, 14-23 (2009)
Chi, S. W., et al., Nature 460, 479-486 (2009)
Azuma-Mukai, A., et al., PNAS 105, 7964-7969 (2008)
Oâ€™Carroll, D., et al., Genes & Dev. 21, 1999-2004 (2007)
Liu, J., et al., Science 305, 1437-1441 (2004)RN001PK RIP-Assay Starter Kit EIF4E (polyclonal)
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RN010PK RIP-Assay Starter Kit MSI1/Musashi1 (polyclonal)

Intended Use:

For Research use only. Not for use in diagnostic procedure.

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