anti-EIF2C2/AGO2

Code No: RN003MW
Datasheet: 
Background: 

Eukaryotic translation initiation factor 2C, subunit 2 (EIF2C2; AGO2), is a member of the argonaute protein family. It is a core component of RNA-induced silencing complex (RISC). The EIF2C2 belonging to the human argonaute protein family possesses endonuclease activity and functions as a slicer in gene silencing pathways. It recognizes and cleaves target mRNA by RNA interference. In small interference RNA (siRNA) pathway, EIF2C2 forms a complex with EIF2C1 and siRNA, and in microRNA (miRNA) pathway, it binds EIF2C3 to miRNA. EIF2C2 expression is controlled by epidermal growth factor receptor and mitogen-activated protein kinase signaling in human breast cancer cell line.

Size: 
100 μL
Application: 
IPP
Application: 
WB
Product Type: 
Primary Antibody
Host Species: 
Mouse
Isotype: 
IgG2a lambda
Storage Temp. (°C): 
4
Shipping Temp. (°C): 
-20
Pictures: 
anti-EIF2C2/AGO2
anti-EIF2C2/AGO2
References: 

Adams, B. D., et al., Endocrinology 150, 14-23 (2009)
Chi, S. W., et al., Nature 460, 479-486 (2009)
Azuma-Mukai, A., et al., PNAS 105, 7964-7969 (2008)
O’Carroll, D., et al., Genes & Dev. 21, 1999-2004 (2007)
Liu, J., et al., Science 305, 1437-1441 (2004)RN001PK RIP-Assay Starter Kit EIF4E (polyclonal)
RN002PK RIP-Assay Starter Kit EIF4G1 (polyclonal)
RN003PK RIP-Assay Starter Kit EIF4G2 (polyclonal)
RN004PK RIP-Assay Starter Kit ELAVL1/HuR (polyclonal)
RN005PK RIP-Assay Starter Kit ELAVL2/HuB (polyclonal)
RN006PK RIP-Assay Starter Kit ELAVL3/HuC (polyclonal)
RN007PK RIP-Assay Starter Kit IGF2BP1/IMP1 (polyclonal)
RN008PK RIP-Assay Starter Kit IGF2BP2/IMP2 (polyclonal)
RN009PK RIP-Assay Starter Kit IGF2BP3/IMP3 (polyclonal)
RN010PK RIP-Assay Starter Kit MSI1/Musashi1 (polyclonal)

Intended Use: 
For Research use only. Not for use in diagnostic procedure.