- Diagnostic Products
- Research Products
|Background:||This Diphtheria toxin was highly purified from growth media as an exotoxin secreted by Corynebacterium diphtheriae strain PW8. Diphtheria toxin is a single polypeptide chain of 535 amino acids (58 kD) consisting of two subunits linked by disulfide bridges . Binding to the cell surface of the less stable of these two subunits allows the more stable part of the protein to penetrate the host cell. It catalyzes the ADPribosylation eucaryotic elongation factor-2 (eEF2) by using NAD, thus inactivating this protein. It does so by ADP-ribosylating the unusual aminoacid diphthamide . In this way, it acts as an inhibitor of protein synthesis.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for Diphtheria toxin Protein at this time.