- Diagnostic Products
- Research Products
|Background:||This Diphtheria toxin CRM197 was highly purified from growth media of Corynebacterium diphtheriae mutant CRM197. CRM197 like wild-typediphtheria toxin is a single polypeptide chain of 535 amino acids (58 kD) consisting of two subunits linked by disulfide bridges . Binding to the cell surface of the less stable of these two subunits allows the more stable part of the protein to penetrate the host cell. Wild-type toxin catalyzes the ADP-ribosylation of eucaryotic elongation factor-2 (eEF2) by using NAD, thus inactivating this protein. However, CRM197 has an alteration of 52nd Gly to Glu and it has no ADP ribosylation activity nor toxicity to cells.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Target:||Diphtheria toxin mutant CRM197|
There are no references for Diphtheria toxin mutant CRM197 Protein at this time.