Solutions for Life Science & Diagnostics
Diphtheria toxin mutant CRM197 Protein
Additional Information
Diphtheria toxin mutant CRM197 Protein Specifications
| Background: | This Diphtheria toxin CRM197 was highly purified from growth media of Corynebacterium diphtheriae mutant CRM197. CRM197 like wild-typediphtheria toxin is a single polypeptide chain of 535 amino acids (58 kD) consisting of two subunits linked by disulfide bridges . Binding to the cell surface of the less stable of these two subunits allows the more stable part of the protein to penetrate the host cell. Wild-type toxin catalyzes the ADP-ribosylation of eucaryotic elongation factor-2 (eEF2) by using NAD, thus inactivating this protein. However, CRM197 has an alteration of 52nd Gly to Glu and it has no ADP ribosylation activity nor toxicity to cells. |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | Protein |
| Shipping: | dry ice |
| Size: | 200 μg |
| Status: | RUO |
| Storage: | -70 |
| Target: | Diphtheria toxin mutant CRM197 |
Applications:
There are no references for Diphtheria toxin mutant CRM197 Protein at this time.
