Sm antibodies are ENA antibodies named after “Smith”, a patient who suffered from Systemic Lupus　Erythematosus (SLE). Sm antibodies are frequently found with RNP antibodies. It is detected in 10-30% of SLE patients. At high levels, Sm antibody is indicative of SLE and is rarely detected in other diseases. It has been adopted as a marker for diagnosis of SLE by the American Rheumatism Association (ARA).Anti-Sm antibodies are observed at a high titer in the active period of SLE and at a low titer in the non-active period. Raynaud’s phenomena and nephropathy are reported more frequently in SLE patients testing positive for anti-Sm antibodies.

The MESACUP-3 TEST Sm measures with high sensitivity, anti-Sm antibodies present in the serum by ELISA.

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