Solutions for Life Science & Diagnostics
Anti-Atg7 (Human) pAb
Additional Information
Anti-Atg7 (Human) pAb Specifications
| Background: | Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Microtubule-associated protein light chain 3 (LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of LC3 is cleaved by a cysteine protease-Atg4, to produce LC3-I, which is located in cytosolic fraction. LC3-I is activated by the E1-like enzyme Atg7 and forms a Atg7-LC3-I thioester. Atg7-LC3-I is transferred to Atg3 to form Atg3-LC3-I thioester. Atg3 is an E2-like enzyme that catalyzes the conjugation of LC3-I and phosphatidylethanolamine (PE) to form LC3-II. The LC3-II-PE conjugate is essential for binding tightly to autophagosomal membrane. |
| Clonality: | Polyclonal |
| Formulation: | In PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 10533 |
| Gene ID Mouse: | 74244 |
| Host Species: | Rabbit |
| Immunogen: | Human Atg 7C-terminal synthetic peptide |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Atg7 |
Applications: IP, WB
| IPP: | 5 μL/300 μL of cell extract from 3x106 |
| WB: | 1:1000-1:2000 |
There are no references for Anti-Atg7 (Human) pAb at this time.
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