Anti-Derlin-1 pAb Specifications
|Background:||Many proteins of eukaryotic cells undergo folding and modification in the endoplasmic reticulum (ER). Properly folded polypeptides leave the ER along the secretory pathway, whereas misfolded proteins or unassembled protein complexes are retained. These proteins are eventually degraded by proteasomes and must therefore be transported back into the cytosol by a multi-step process called retro-translocation, dislocation, or ERAD (ER-associated protein degradation). The S. cerevisiae Der1 was identified in a genetic screen for components required for the degradation of misfolded luminal ER proteins and the Der1 homologue Derlin-1 is found in every eukaryotic organism. All species contain at least one other related protein, called Derlin-2, that belongs to a distinct group. Mammalian Derlin-1 is predicted to have four transmembrane segments with both the amino and carboxy termini in the cytosol.
|Formulation:||In PBS/50% glycerol, pH 7.2|
|Gene ID Human:||79139|
|Immunogen:||KLH-conjugated Derlin-1 C-terminal peptide (239-251 a.a.)|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||Human, Mouse|
Applications: IC, IP, WB
|IPP:||1 uL/250 uL of cell extract from 5x106 |
|WB:||1:1,000 (for chemiluminescence detection system)|
There are no references for Anti-Derlin-1 pAb at this time.