Solutions for Life Science & Diagnostics
Anti-Phospho Lamin A (Ser458) pAb
Additional Information
Anti-Phospho Lamin A (Ser458) pAb Specifications
| Background: | The nuclear lamina is constituted with lamin proteins that are members of the intermediate filament protein family underlying the inner nuclear membrane. The nuclear lamina decides nuclear shape and size, and carries important functions such as the reinforcement of nuclear membrane or chromatin bindings. The lamin A/C gene (LMNA) encodes two proteins, lamin A and C, produced by alternative splicing in the nuclear lamina. LMNA gene locates chromosome 1q11-q21, and the mutations of this gene are associated with Autosomal Emery-Dreifuss muscular dystrophy (EDMD), Limb-girdle muscular dystrophy type 1B (LGMD1B), dilated cardiomyopathy (DCM), Charcot-Marie-Tooth disease type 2 (CMT2B1), Hutchinson-Gilford progeria syndrome (HGPS), mandibuloacral dysplasia (MAD), and Dunnigan-type familial partial lIPPodystrophy (FPLD).　Phosphorylation of lamin A/C proteins causes lamina disassembly during meiotic and mitotic M phase. Specific phosphorylation on Ser458 of lamin A/C is observed in EDMD and LGMD1B patients with the mutation in the C-terminal Ig-fold domain1). |
| Clonality: | Polyclonal |
| Formulation: | In PBS/50% glycerol, pH7.2 |
| Host Species: | Rabbit |
| Immunogen: | synthetic peptide CLRNK[pS]NEDQS, corresponding to the amino acid residues 454-463 of human Lamin A |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μL |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Lamin A |
Applications: IC, IH, WB
| ICC: | 1:100 |
| IHC: | 1:100-1:200 |
| WB: | 1:500 |
There are no references for Anti-Phospho Lamin A (Ser458) pAb at this time.
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