Anti-PDCD4 (Human) pAb
Anti-PDCD4 (Human) pAb Specifications
|Background:||The human programmed cell death 4 (PDCD4) gene was first identified from a human glioma cDNA library as a tumor-related gene and localized to chromosome 10q24. It is highly conserved from Drosophila to vertebrates and is ubiquitously expressed in normal tissues but gene expression is suppressed in many carcinoma tissues although it is frequently expressed in tumor tissues such as breast cancers. PDCD4 inhibits TPA-induced neoplastic transformation of epidermal cells and or inhibits transactivation of transcrIPPtion factor AP-1. Therefore PDCD4 regards as a tumor suppressor gene. PDCD4 contains 2 a-helical MA3 domains homologous to the M1 domain of the translation initiation factor eIF4G and it is important for binding to the eukaryotic initiation factor eIF4A which is a member of RNA helicase protein family. The RNA helicase activity of eIF4A is reduced or inactivated by its binding with PDCD4, which may result in inhibition of translation of 5Ã¢â‚¬â„¢UTR structured mRNA. Beside the control of translation, the protein also regulates some transcrIPPtions. PDCD4 is a functional target of miR21.
|Formulation:||In PBS/50% glycerol, pH 7.2|
|Gene ID Human:||27250|
|Gene ID Mouse:||18569|
|Immunogen:||synthetic peptide DVENEQILNVNPAD (2-15 aa)|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: IC, IH, IP, WB
|IHC:||1:100 (Heat treatment is necessary for paraffin em|
|IPP:||5 μL/300 uL of cell extract from 3x106 |
There are no references for Anti-PDCD4 (Human) pAb at this time.