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|Background:||The 20S proteasome is composed of 28 subunits, arranged as a cylinder-shaped structure made of four stacked hetero-heptameric rings: ï¡1-7, ï¢1-7, ï¢1-7, and ï¡1-7. ï¢1, ï¢2, and ï¢5 function the catalytic subunit for proteolysis. Murata and colleagues recently identified a new catalytic ï¢ subunit called ï¢5t, which is only expressed in thymic cortical epithelial cells and dominantly incorporated into thymic 20S proteasomes. The integration of ï¢5t into proteasomes reduces their chymotrypsin-like activity responsible for producing high affinity peptides for MHC class I. The depletion of ï¢5t in mice resulted in defective development of CD8 single positive T cells in the thymus, indicating that ï¢5t has a key role for generating the MHC class I-restricted CD8+T cell repertoire during thymic selection. There results challenge the 15 years old theory of T-cell development, particularly positive selection in the thymus and the phenomenon of peripheral tolerance.|
|Gene ID Human:||122706|
|Gene ID Mouse:||73902|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Mouse β5t polyclonal antibody : Trial Size at this time.