Solutions for Life Science & Diagnostics
Anti-Phosphorylated GFAP (Ser8) mAb
Additional Information
Anti-Phosphorylated GFAP (Ser8) mAb Specifications
| Background: | Intermediate filaments (IFs) constitute major components of the cytoskeleton and the nuclear envelope in most cell types. Unlike other cytoskeletons such as microtubules and actin filaments, the protein components of IFs vary in a cell-, tissue-, and differentiation-dependent manner. Although IFs were thought to be relatively stable compared with actin filaments and microtubules, intensive in vitro investigations revealed that site-specific phosphorylation by several kinases, such as protein kinase A (PKA), protein kinase C (PKC), Ca2+/Calmodulin kinase II (CaMKII), cdc2 kinase, Aurora-B, and Rho-kinase alters dynamically their structure and induces filament disruption. Glial fibrillary acidic protein (GFAP) belongs to IF proteins. GFAP is a useful marker of mature astrocytes and mutation in the GFAP gene has recently been associated with Alexander disease. Inagaki et al. reported that Cdc2 kinase phosphorylates GFAP at Ser8, which appeared at G2-M phase transition in the entire cytoplasm. Rho-kinase phosphorylates GFAP at Ser13 and Ser34 but not at Ser8. |
| Clonality: | Monoclonal |
| Clone Number: | YC10 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 2670 |
| Gene ID Mouse: | 14580 |
| Host Species: | Mouse |
| Immunogen: | KLH-phophorylated GFAPsynthetic peptide (3-13 a.a.) (RRRVT(p)SAARRS) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 50 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | GFAP |
Applications: IC, WB
| ICC: | 10 μg/mL |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Phosphorylated GFAP (Ser8) mAb at this time.
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