Angiogenesis
Apoptosis
Autophagy & Proteolysis
Cancer & Cell Proliferation
Cell Surface Antigens
Cellular Stress
Cytokines & Growth Factors
Epigenetics
Epitope Tags
Fluorescent Proteins
GPCR
In Vitro Diagnostics
Inflammation & Immunology
Metabolism
Molecular Biology
Neuroscience
Signal Transduction
Solute Carrier
Virology
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Product Catalog |
Rb Gene product, Human, Monoclonal Antibody : Trial SizeCode No: MK-15-1S
Target:
Rb Background:
Mutation of the retinoblastoma tumor suppressor gene alone is sufficient to cause retinoblastoma in humans, suggesting that it might play a role in the normal coordination of cell proliferation and cell death. Deletion or mutational inactivation of the retinoblastoma tumor suppressor protein (Rb) is correlated with the genesis of a variety of human cancers including retinoblastoma, osteosarcoma, and carcinomas of the breast, bladder, and lung. Rb protein is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of Rb. Rb undergo phosphorylation and attendant functional inactivation, the cell proceed into late G1.
Size:
10 µg
Application:
WB
Application:
IHC
Clone Number:
3H9
Concentration:
0.1mg/,L
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Isotype:
IgG2a k
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Lalande, M., et al. Cancer Genet.Cytogenet. 13, Formulation:
10 g IgG in 100 L volume of PBS containing 0.1% Sodium azide as preservative.Sodium azide has been reported to form potentially explosive lead or copper azide in plumbing. To prevent forming of these compounds, flush drains enough after disposing of solutions containing sodium azide.
Reactivity:
This antibody reacts with human retinoblastoma gene product (110-115 kDa).
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
