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Cyclin D1/Bcl-1, Human : Trial Size

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Code No: MD-17-3S
Datasheet: 
application/pdf iconMD-17-3S.pdf
FID:5686 | PATH:sites/default/files/datasheets/MD-17-3S.PDF
Gene/antigen ID number: 
595
Target: 

Cyclin D1

Background: 

Cyclin D1, also known as Bcl-1, CCND1, or PRAD1, is a 36 kDa nuclear protein that plays a key regulatory role during the G1 phase of the cell cycle by regulating the activity of Cdk proteins. Cyclin D1 forms a complex with Cdk4, then binds to and phosphorylates Rb protein, triggering cells to progress from G0/G1 to S and thus driving cellular proliferation. Cyclin D1 protein overexpression is found in the majority of human breast cancers and is usually linked with poor prognosis. Overexpression of cyclin D1 is a well-established criterion for the diagnosis of Mantle Cell Lymphoma, and also has been used to distinguish malignant breast carcinomas from premalignant breast lesions.

Size: 
10 µg
Application: 
WB
Application: 
IHC
Clone Number: 
5D4
Conjugate: 
agarose
Product Type: 
Primary Antibody
Host Species: 
Mouse
Species Reactivities: 
Human
Species Reactivities: 
Mouse
Isotype: 
IgG2a
Storage Temp. (°C): 
4
Shipping Temp. (°C): 
4
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References: 

1) Tokugawa, T., et al., Cancer Res. 62, 4938-4944 (2002)
2) Inagaki, H., et al., Am. J. Pathol. 160, 1435-1443 (2002)
3) Kumazawa, Y., et al., Mol. Pathol. 55, 61-64 (2002)
4) Igarashi, T., et al., Ann. Onc. 13, 928-943 (2002)
5) Chung, D. C., et al., J. Clin. Endocrinol. Metab. 85, 4373-4378 (2000)
6) Imanishi, Y., et al., J. Clin. Invest. 107, 1093-1102 (2001)
7) Jensen, S. S., et al., Mol. Endocrinol. 15, 1370-1380 (2001)
8) Oyama, T., et al., Cancer Res. 58, 2876-2880 (1998)
9) Bartkova, J., et al., Cancer Res. 56, 5475-5483 (1996)

Reactivity: 
This antibody reacts with human CyclinD1 (36 kDa) on Western blotting, Immunoprecipitation,Immunohistochemistry and Flow cytometry. This clone5D4 recognizes human Cyclin D1, D2 and mouse CyclinD1, D2, but not human and mouse Cyclin D3.
Intended Use: 
For Research use only. Not for use in diagnostic procedure.
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