Solutions for Life Science & Diagnostics
Anti-MAP kinase kinase (MEK1) mAb
Additional Information
Anti-MAP kinase kinase (MEK1) mAb Specifications
| Background: | The MAP kinases mediate a wide range of cellular functions via a variety of signal transduction pathways in eukaryotic cells. The most studied mammalian MAP kinase pathway is the Ras-Raf-MEK-ERK pathway. The binding of GTP to Ras protein initiates a phosphorylation cascade through Raf-1 and MEK1/2 (MAPK kinase), which results in stimulation of the MAP kinases, ERK1/2. Upon stimulation, ERKs are known to phosphorylate a variety of cytosolic substrates and are also translocated into the nucleus where they initiate the transcription of immediate early genes. The Ras-Raf-MEK-ERK pathway is stimulated by various growth factors and extracellular stimuli and plays important roles in cell survival, differentiation and proliferation. The observation that MEK1/2 inhibitors potentiate the antitumor activity of various cytotoxic agents, including ara-C, cisplatin and paclitaxel, suggests a possible role for MEK1/2 inhibitors in the treatment of human malignancies. |
| Clonality: | Monoclonal |
| Clone Number: | 4A5 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 27352 |
| Gene ID Mouse: | 105835 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Xenopus MAPKK |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µl |
| Species Reactivities: | Human, Mouse, Rat, Xenopus |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | MAP |
Applications: IP, WB
| IPP: | 5-10 μg/200 μL cell extract from 5x106 |
| WB: | 1-5 μg/mL |
There are no references for Anti-MAP kinase kinase (MEK1) mAb at this time.
Product Images
