CD80/B7-1-Alexa Fluor® 647

Datasheet:

Target:

CD80

Background:

CD80 is a 60 kDa, single chain, type I glycoprotein belonging to the immunoglobulin superfamily. It is also known as B7-1, B7, and BB1. CD80 is expressed by activated B and T cells, macrophages, and dendritic cells. CD80 binds to two T cell surface antigens: CD28 and CD152 (CTLA-4). The interaction of CD80 with CD28 provides a costimulatory signal for the activation of T cells that recognize a particular peptide antigen loaded on the MHC molecule. CTLA-4 binds to CD80 with approximately 20 times more affinity than CD28 and provides an inhibitory signal to activated T cells.

Size:

50 µL

Application:

FCM

Product Type:

Primary Antibody

Host Species:

Mouse

Species Reactivities:

Human

Isotype:

IgG2a k

Storage Temp. (°C):

4

Shipping Temp. (°C):

4

Pictures:

References:

1) Stephan, M. T., et al., Nat. Med. 13, 1440-1449 (2007)
2) Reiser, J., et al., J. Clin. Invest. 113, 1390-1397 (2004)
3) Stamper, C. C., et al., Nature 410, 608-611 (2001)
4) Selvakumar, A., et al., Immunogenetics 36, 175-181 (1992)

Intended Use:

For Research use only. Not for use in diagnostic procedure.

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