Anti-IL-18 (Rat) mAb
Anti-IL-18 (Rat) mAb Specifications
|Background:||Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-ï§ (IFN-ï§) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-ï§ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-ï§ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-ï§ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-ï§. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-ï§ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-ï§ in T cells, enhancement of Fas ligand expression by Th1 cells.
|Formulation:||1 mg/mL in PBS/50% glycerol, pH 7.2|
|Gene ID Human:||3606|
|Gene ID Mouse:||16173|
|Immunogen:||mature rat IL-18 fusion protein (37-194 aa)|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Isotype:||IgG2b k |
|Product Type:||Primary Antibody|
There are no references for Anti-IL-18 (Rat) mAb at this time.