Solutions for Life Science & Diagnostics
Anti-SUMO-1 (Human) mAb
Additional Information
Anti-SUMO-1 (Human) mAb Specifications
| Background: | Sumoylation, the covalent attachment of a small ubiquitin-like modifier (SUMO) peptide to lysine residues of targeted substrate, has recently emerged as an important mechanism in transcrIPPtional control. The 15~17 kDa SUMO-1/UBL1/Sentrin is processed by SUMO hydrolase / isopeptidase to generate a free glycine residue that covalently attaches to protein substrates. Unlike ubiquitin, SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of protein-protein interactions. SUMO modification represses the activity of targeted transcrIPPtional activators by altering their subcompartmentalization and binding properties. Sumoylation also recruits histone deacetylases, leading to SUMO-dependent transcrIPPtional repression. Major SUMO-1 substrates include RanGAP1, PML, SP100, p53, Mdm2, c-Jun, topoisomerase I and II, and Iï« B. |
| Clonality: | Monoclonal |
| Clone Number: | 5B12 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 7341 |
| Gene ID Mouse: | 22218 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human fulll length SUMO-1 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | SUMO1 |
Applications: IC, WB
| ICC: | 5 ug/mL |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-SUMO-1 (Human) mAb at this time.
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