Solutions for Life Science & Diagnostics
Anti-HRF (TCTP) (Human) mAb
Additional Information
Anti-HRF (TCTP) (Human) mAb Specifications
| Background: | The pathophysiological events of human allergic disease are characterized by infiltration of inflammatory cells and by the presence of mediators such as histamine. An IgE-dependent histamine releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. HRF, also known as TCTP (Translationally Controlled Tumor Protein), Fortilin, Tumor protein-1 (Tpt-1), lens epithelial protein and p23, is as a 21 or 23 kDa protein produced in a variety of mouse and human cell lines, respectively1). HRF binds to a unique species of IgE on the surface of mast cells and basophils and thereby causes histamine release. The histamine released in late-phase reaction (LPR) of chronic allergic diseases such as asthma results from activation of basophils, eosinophils and lymphocytes infiltrate tissues during this response 2-4). |
| Clonality: | Monoclonal |
| Clone Number: | 6E9 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 7178 |
| Gene ID Mouse: | 22070 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human fulll length HRF |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | HRF/TCTP |
Applications: IH, WB
| IHC: | 5 ug/mL (Heat treatment is necessary for paraffin |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-HRF (TCTP) (Human) mAb at this time.
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