Solutions for Life Science & Diagnostics
Anti-MCM2 (Human) mAb
Additional Information
Anti-MCM2 (Human) mAb Specifications
| Background: | Minichromosome Maintenance (MCM) proteins play an essential role in eukaryotic DNA replication. Six MCM proteins (MCM2-7) have been identified from yeast to mammals. In human cells, MCM4, -6, and -7 proteins form a stable complex, and MCM2 is loosely associated with this complex. The heterotrimeric MCM complex containing MCM4, -6 and -7 has DNA helicase activity, and such activity can be inhibited by the presence of MCM2. Cdc7/Dbf4 protein kinase, which is required for the initiation of DNA replication phosphorylates MCM2 in vitro and in vivo. From these observations, it is thought that phosphorylation of MCM2 may remove MCM2 from the MCM4, -6, and -7 complex to activate its DNA helicase activity at the onset of DNA replication. |
| Clonality: | Monoclonal |
| Clone Number: | 4B8 |
| Formulation: | 0.2 mg/mL in PBS/1% BSA/10% glycerol/0.09% sodium azide |
| Gene ID Human: | 4171 |
| Gene ID Mouse: | 17216 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human fulll length MCM2 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 10 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | Mcm2 |
Applications: IC, WB
| ICC: | 5-10 μg/mL |
| WB: | 1 μg/mL |
There are no references for Anti-MCM2 (Human) mAb at this time.
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